Skip to main content
Journal cover image

Spatial guidance of cell asymmetry: septin GTPases show the way.

Publication ,  Journal Article
Spiliotis, ET; Gladfelter, AS
Published in: Traffic
February 2012

Eukaryotic cells develop asymmetric shapes suited for specific physiological functions. Morphogenesis of polarized domains and structures requires the amplification of molecular asymmetries by scaffold proteins and regulatory feedback loops. Small monomeric GTPases signal polarity, but how their downstream effectors and targets are spatially co-ordinated to break cell symmetry is poorly understood. Septins comprise a novel family of GTPases that polymerize into non-polar filamentous structures which scaffold and restrict protein localization. Recent studies show that septins demarcate distinct plasma membrane domains and cytoskeletal tracks, enabling the formation of intracellular asymmetries. Here, we review these findings and discuss emerging mechanisms by which septins promote cell asymmetry in fungi and animals.

Duke Scholars

Published In

Traffic

DOI

EISSN

1600-0854

Publication Date

February 2012

Volume

13

Issue

2

Start / End Page

195 / 203

Location

England

Related Subject Headings

  • Septins
  • Saccharomyces cerevisiae
  • Humans
  • Developmental Biology
  • Cell Shape
  • Cell Polarity
  • Animals
  • 3101 Biochemistry and cell biology
  • 1108 Medical Microbiology
  • 0601 Biochemistry and Cell Biology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Spiliotis, E. T., & Gladfelter, A. S. (2012). Spatial guidance of cell asymmetry: septin GTPases show the way. Traffic, 13(2), 195–203. https://doi.org/10.1111/j.1600-0854.2011.01268.x
Spiliotis, Elias T., and Amy S. Gladfelter. “Spatial guidance of cell asymmetry: septin GTPases show the way.Traffic 13, no. 2 (February 2012): 195–203. https://doi.org/10.1111/j.1600-0854.2011.01268.x.
Spiliotis ET, Gladfelter AS. Spatial guidance of cell asymmetry: septin GTPases show the way. Traffic. 2012 Feb;13(2):195–203.
Spiliotis, Elias T., and Amy S. Gladfelter. “Spatial guidance of cell asymmetry: septin GTPases show the way.Traffic, vol. 13, no. 2, Feb. 2012, pp. 195–203. Pubmed, doi:10.1111/j.1600-0854.2011.01268.x.
Spiliotis ET, Gladfelter AS. Spatial guidance of cell asymmetry: septin GTPases show the way. Traffic. 2012 Feb;13(2):195–203.
Journal cover image

Published In

Traffic

DOI

EISSN

1600-0854

Publication Date

February 2012

Volume

13

Issue

2

Start / End Page

195 / 203

Location

England

Related Subject Headings

  • Septins
  • Saccharomyces cerevisiae
  • Humans
  • Developmental Biology
  • Cell Shape
  • Cell Polarity
  • Animals
  • 3101 Biochemistry and cell biology
  • 1108 Medical Microbiology
  • 0601 Biochemistry and Cell Biology