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Association between goal-striving stress and rapid kidney function decline among African Americans: the Jackson Heart Study.

Publication ,  Journal Article
Cain-Shields, L; Glover, L; Young, B; Sims, M
Published in: J Investig Med
February 2021

African Americans (AAs) are disproportionately affected by kidney disease and also report higher psychosocial stressors than other racial groups. Goal-striving stress (GSS) is an understudied psychosocial stressor related to attempting to accomplish one's life goals. Given the numerous social determinants that contribute to health inequities among AAs, stress from goal striving may also disproportionately affect the health of AAs and in particular kidney disease outcomes. The objective of this study was to explore the association between GSS and rapid kidney function decline (RKFD) in an AA cohort. Using examination 1 (2000-2004) and examination 3 (2009-2013) data from the Jackson Heart Study (n=2630), we examined associations of baseline levels of GSS with RKFD among AAs using multivariable Poisson regression models, adjusting for sociodemographics, health behaviors, chronic disease and discrimination. We also explored baseline cortisol as a mediator. The incidence of RKFD in this sample was 7.34% (mean years of follow-up: 8.06±0.84 years). The mean GSS score was 3.80 (±4.88) and total GSS score ranged from 0 to 36. Those who reported high (vs low) GSS were 1.60 times more likely to experience RKFD after full adjustment (incidence rate ratio (IRR) 1.60; 95% CI 1.11 to 2.14, p=0.01). After confirming cortisol as a mediator and adding it to the model, those who reported high (vs low) GSS had 1.58 times the rate of RKFD (IRR 1.58; 95% CI 1.09 to 2.30, p=0.0153). Stress related to not achieving goals was associated with a greater risk of RKFD in this sample of AAs.

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Published In

J Investig Med

DOI

EISSN

1708-8267

Publication Date

February 2021

Volume

69

Issue

2

Start / End Page

382 / 387

Location

England

Related Subject Headings

  • Stress, Psychological
  • Risk Factors
  • Prospective Studies
  • Longitudinal Studies
  • Kidney Diseases
  • Kidney
  • Hydrocortisone
  • Humans
  • Health Inequities
  • Goals
 

Citation

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ICMJE
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Cain-Shields, L., Glover, L., Young, B., & Sims, M. (2021). Association between goal-striving stress and rapid kidney function decline among African Americans: the Jackson Heart Study. J Investig Med, 69(2), 382–387. https://doi.org/10.1136/jim-2020-001510
Cain-Shields, Loretta, LáShauntá Glover, Bessie Young, and Mario Sims. “Association between goal-striving stress and rapid kidney function decline among African Americans: the Jackson Heart Study.J Investig Med 69, no. 2 (February 2021): 382–87. https://doi.org/10.1136/jim-2020-001510.
Cain-Shields L, Glover L, Young B, Sims M. Association between goal-striving stress and rapid kidney function decline among African Americans: the Jackson Heart Study. J Investig Med. 2021 Feb;69(2):382–7.
Cain-Shields, Loretta, et al. “Association between goal-striving stress and rapid kidney function decline among African Americans: the Jackson Heart Study.J Investig Med, vol. 69, no. 2, Feb. 2021, pp. 382–87. Pubmed, doi:10.1136/jim-2020-001510.
Cain-Shields L, Glover L, Young B, Sims M. Association between goal-striving stress and rapid kidney function decline among African Americans: the Jackson Heart Study. J Investig Med. 2021 Feb;69(2):382–387.

Published In

J Investig Med

DOI

EISSN

1708-8267

Publication Date

February 2021

Volume

69

Issue

2

Start / End Page

382 / 387

Location

England

Related Subject Headings

  • Stress, Psychological
  • Risk Factors
  • Prospective Studies
  • Longitudinal Studies
  • Kidney Diseases
  • Kidney
  • Hydrocortisone
  • Humans
  • Health Inequities
  • Goals