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T lymphocyte abnormalities in juvenile systemic sclerosis patients.

Publication ,  Journal Article
Reiff, A; Weinberg, KI; Triche, T; Masinsin, B; Mahadeo, KM; Lin, C-H; Brown, D; Parkman, R
Published in: Clin Immunol
October 2013

Multi-center evaluations of pediatric patients with juvenile systemic sclerosis (jSSc) have suggested that the pathogenesis of jSSc may differ from that of systemic sclerosis (SSc) in adult patients. Therefore, we undertook to identify abnormalities in the T lymphocytes of jSSc patients and to determine if they differed from the abnormalities reported in the T lymphocytes of adult SSc patients. We identified decreases in the frequency of resting regulatory T lymphocytes and an increased frequency of CD45RA expressing effector memory (EMRA) CD4 T lymphocytes, which were characterized by an increased frequency of CCR7 protein expressing cells. Neither the increases in the EMRA subpopulation nor the increased CCR7 protein expression have been reported in adult SSc patients. The decrease in resting regulatory T lymphocytes in jSSc patients may permit the expansion of the disease initiating CD4 T lymphocytes present in the CCR7 expressing EMRA CD4 T lymphocyte subpopulation.

Duke Scholars

Published In

Clin Immunol

DOI

EISSN

1521-7035

Publication Date

October 2013

Volume

149

Issue

1

Start / End Page

146 / 155

Location

United States

Related Subject Headings

  • Young Adult
  • T-Lymphocyte Subsets
  • Scleroderma, Systemic
  • Receptors, CCR7
  • Oligonucleotide Array Sequence Analysis
  • Male
  • Immunology
  • Humans
  • Gene Expression Profiling
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Reiff, A., Weinberg, K. I., Triche, T., Masinsin, B., Mahadeo, K. M., Lin, C.-H., … Parkman, R. (2013). T lymphocyte abnormalities in juvenile systemic sclerosis patients. Clin Immunol, 149(1), 146–155. https://doi.org/10.1016/j.clim.2013.07.005
Reiff, Andreas, Kenneth I. Weinberg, Timothy Triche, Bernadette Masinsin, Kris M. Mahadeo, Chuan-Hao Lin, Diane Brown, and Robertson Parkman. “T lymphocyte abnormalities in juvenile systemic sclerosis patients.Clin Immunol 149, no. 1 (October 2013): 146–55. https://doi.org/10.1016/j.clim.2013.07.005.
Reiff A, Weinberg KI, Triche T, Masinsin B, Mahadeo KM, Lin C-H, et al. T lymphocyte abnormalities in juvenile systemic sclerosis patients. Clin Immunol. 2013 Oct;149(1):146–55.
Reiff, Andreas, et al. “T lymphocyte abnormalities in juvenile systemic sclerosis patients.Clin Immunol, vol. 149, no. 1, Oct. 2013, pp. 146–55. Pubmed, doi:10.1016/j.clim.2013.07.005.
Reiff A, Weinberg KI, Triche T, Masinsin B, Mahadeo KM, Lin C-H, Brown D, Parkman R. T lymphocyte abnormalities in juvenile systemic sclerosis patients. Clin Immunol. 2013 Oct;149(1):146–155.
Journal cover image

Published In

Clin Immunol

DOI

EISSN

1521-7035

Publication Date

October 2013

Volume

149

Issue

1

Start / End Page

146 / 155

Location

United States

Related Subject Headings

  • Young Adult
  • T-Lymphocyte Subsets
  • Scleroderma, Systemic
  • Receptors, CCR7
  • Oligonucleotide Array Sequence Analysis
  • Male
  • Immunology
  • Humans
  • Gene Expression Profiling
  • Female