Systemic mastocytosis in a child with t(8;21) acute myeloid leukemia.
Publication
, Journal Article
Mahadeo, KM; Wolgast, L; McMahon, C; Cole, PD
Published in: Pediatr Blood Cancer
October 2011
Mastocytosis is primarily limited to the cutaneous variant in pediatric patients. Systemic mastocytosis (SM) has been associated with t(8;21) acute myeloid leukemia (AML) in adults. We provide the first report of a child with t(8;21) AML, diagnosed with asymptomatic SM following four cycles of chemotherapy. Unlike most adults with SM/AML, she was not found to have a c-KIT (D816V) mutation. SM persisted in the bone marrow after completion of chemotherapy, and her AML relapsed 9 months off-treatment. Although she achieved a second remission, mastocytosis persists in the marrow. Pediatric patients with t(8;21) AML/SM may represent a high-risk group despite favorable cytogenetics.
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Published In
Pediatr Blood Cancer
DOI
EISSN
1545-5017
Publication Date
October 2011
Volume
57
Issue
4
Start / End Page
684 / 687
Location
United States
Related Subject Headings
- Oncology & Carcinogenesis
- Neoplasm Recurrence, Local
- Mastocytosis, Systemic
- Leukemia, Myeloid, Acute
- Immunophenotyping
- Immunohistochemistry
- Humans
- Flow Cytometry
- Female
- Chromosomes, Human, Pair 8
Citation
APA
Chicago
ICMJE
MLA
NLM
Mahadeo, K. M., Wolgast, L., McMahon, C., & Cole, P. D. (2011). Systemic mastocytosis in a child with t(8;21) acute myeloid leukemia. Pediatr Blood Cancer, 57(4), 684–687. https://doi.org/10.1002/pbc.23026
Mahadeo, Kris M., Lucia Wolgast, Christine McMahon, and Peter D. Cole. “Systemic mastocytosis in a child with t(8;21) acute myeloid leukemia.” Pediatr Blood Cancer 57, no. 4 (October 2011): 684–87. https://doi.org/10.1002/pbc.23026.
Mahadeo KM, Wolgast L, McMahon C, Cole PD. Systemic mastocytosis in a child with t(8;21) acute myeloid leukemia. Pediatr Blood Cancer. 2011 Oct;57(4):684–7.
Mahadeo, Kris M., et al. “Systemic mastocytosis in a child with t(8;21) acute myeloid leukemia.” Pediatr Blood Cancer, vol. 57, no. 4, Oct. 2011, pp. 684–87. Pubmed, doi:10.1002/pbc.23026.
Mahadeo KM, Wolgast L, McMahon C, Cole PD. Systemic mastocytosis in a child with t(8;21) acute myeloid leukemia. Pediatr Blood Cancer. 2011 Oct;57(4):684–687.
Published In
Pediatr Blood Cancer
DOI
EISSN
1545-5017
Publication Date
October 2011
Volume
57
Issue
4
Start / End Page
684 / 687
Location
United States
Related Subject Headings
- Oncology & Carcinogenesis
- Neoplasm Recurrence, Local
- Mastocytosis, Systemic
- Leukemia, Myeloid, Acute
- Immunophenotyping
- Immunohistochemistry
- Humans
- Flow Cytometry
- Female
- Chromosomes, Human, Pair 8