Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year-old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury.
Publication
, Journal Article
Mahadeo, KM; Dhall, G; Panigrahy, A; Lastra, C; Ettinger, LJ
Published in: Pediatr Hematol Oncol
February 2010
From as early as the 1970s methotrexate has been associated with disseminated necrotizing leukoencephalopathy and other neurotoxic sequelae. Yet, a clear mechanism for methotrexate-induced neurotoxicity has not been established. The authors describe the case of a 12-year-old male with acute lymphoblastic leukemia and a homozygous methylenetetrahydrofolate reductase C677T mutation, who developed subacute methotrexate-induced toxicity and cerebral venous thrombosis after receiving intrathecal methotrexate. The role of homocysteine as a possible mediator in methotrexate-induced neurotoxicity via direct endothelial injury is discussed.
Duke Scholars
Published In
Pediatr Hematol Oncol
DOI
EISSN
1521-0669
Publication Date
February 2010
Volume
27
Issue
1
Start / End Page
46 / 52
Location
England
Related Subject Headings
- Vincristine
- Sinus Thrombosis, Intracranial
- Remission Induction
- Prednisone
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
- Polymorphism, Single Nucleotide
- Oncology & Carcinogenesis
- Methylenetetrahydrofolate Reductase (NADPH2)
- Methotrexate
- Male
Citation
APA
Chicago
ICMJE
MLA
NLM
Mahadeo, K. M., Dhall, G., Panigrahy, A., Lastra, C., & Ettinger, L. J. (2010). Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year-old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury. Pediatr Hematol Oncol, 27(1), 46–52. https://doi.org/10.3109/08880010903341904
Mahadeo, Kris M., Girish Dhall, Ashok Panigrahy, Carlos Lastra, and Lawrence J. Ettinger. “Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year-old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury.” Pediatr Hematol Oncol 27, no. 1 (February 2010): 46–52. https://doi.org/10.3109/08880010903341904.
Mahadeo KM, Dhall G, Panigrahy A, Lastra C, Ettinger LJ. Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year-old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury. Pediatr Hematol Oncol. 2010 Feb;27(1):46–52.
Mahadeo, Kris M., et al. “Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year-old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury.” Pediatr Hematol Oncol, vol. 27, no. 1, Feb. 2010, pp. 46–52. Pubmed, doi:10.3109/08880010903341904.
Mahadeo KM, Dhall G, Panigrahy A, Lastra C, Ettinger LJ. Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year-old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury. Pediatr Hematol Oncol. 2010 Feb;27(1):46–52.
Published In
Pediatr Hematol Oncol
DOI
EISSN
1521-0669
Publication Date
February 2010
Volume
27
Issue
1
Start / End Page
46 / 52
Location
England
Related Subject Headings
- Vincristine
- Sinus Thrombosis, Intracranial
- Remission Induction
- Prednisone
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
- Polymorphism, Single Nucleotide
- Oncology & Carcinogenesis
- Methylenetetrahydrofolate Reductase (NADPH2)
- Methotrexate
- Male