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The role of neutrophils in thrombosis.

Publication ,  Journal Article
Kapoor, S; Opneja, A; Nayak, L
Published in: Thromb Res
October 2018

Despite significant evidence implicating an important role for neutrophils in thrombosis, their impact on the thrombotic process has remained a matter of controversy. Until 2010, platelets, coagulation factors, fibrinogen and monocytes were implicated in the thrombotic process. Several studies conducted over the last decade now support the growing notion that neutrophils indeed do contribute significantly to this process. Neutrophils can contribute to pathologic venous and arterial thrombosis or 'immunothrombosis' by the release of neutrophil extracellular traps (NETs) and NET release is emerging as a major contributor to thrombogenesis in pathologic situations such as sepsis and malignancy. Further, blood-cell derived microparticles, including those from neutrophils, have been implicated in thrombus formation. Finally, inflammasome activation in the neutrophil identifies another important mechanism that may be operative in neutrophil-driven risk for thrombosis. The knowledge of these roles of neutrophils in thrombosis may pave the road for novel anti-thrombotic agents in the future that do not affect hemostasis.

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Published In

Thromb Res

DOI

EISSN

1879-2472

Publication Date

October 2018

Volume

170

Start / End Page

87 / 96

Location

United States

Related Subject Headings

  • Thrombosis
  • Neutrophils
  • Humans
  • Cardiovascular System & Hematology
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences
 

Citation

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Kapoor, S., Opneja, A., & Nayak, L. (2018). The role of neutrophils in thrombosis. Thromb Res, 170, 87–96. https://doi.org/10.1016/j.thromres.2018.08.005
Kapoor, Sargam, Aman Opneja, and Lalitha Nayak. “The role of neutrophils in thrombosis.Thromb Res 170 (October 2018): 87–96. https://doi.org/10.1016/j.thromres.2018.08.005.
Kapoor S, Opneja A, Nayak L. The role of neutrophils in thrombosis. Thromb Res. 2018 Oct;170:87–96.
Kapoor, Sargam, et al. “The role of neutrophils in thrombosis.Thromb Res, vol. 170, Oct. 2018, pp. 87–96. Pubmed, doi:10.1016/j.thromres.2018.08.005.
Kapoor S, Opneja A, Nayak L. The role of neutrophils in thrombosis. Thromb Res. 2018 Oct;170:87–96.
Journal cover image

Published In

Thromb Res

DOI

EISSN

1879-2472

Publication Date

October 2018

Volume

170

Start / End Page

87 / 96

Location

United States

Related Subject Headings

  • Thrombosis
  • Neutrophils
  • Humans
  • Cardiovascular System & Hematology
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences