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Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records.

Publication ,  Journal Article
Thompson, EJ; Williams, DM; Walker, AJ; Mitchell, RE; Niedzwiedz, CL; Yang, TC; Huggins, CF; Kwong, ASF; Silverwood, RJ; Di Gessa, G; Hou, B ...
Published in: Nature communications
June 2022

The frequency of, and risk factors for, long COVID are unclear among community-based individuals with a history of COVID-19. To elucidate the burden and possible causes of long COVID in the community, we coordinated analyses of survey data from 6907 individuals with self-reported COVID-19 from 10 UK longitudinal study (LS) samples and 1.1 million individuals with COVID-19 diagnostic codes in electronic healthcare records (EHR) collected by spring 2021. Proportions of presumed COVID-19 cases in LS reporting any symptoms for 12+ weeks ranged from 7.8% and 17% (with 1.2 to 4.8% reporting debilitating symptoms). Increasing age, female sex, white ethnicity, poor pre-pandemic general and mental health, overweight/obesity, and asthma were associated with prolonged symptoms in both LS and EHR data, but findings for other factors, such as cardio-metabolic parameters, were inconclusive.

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Published In

Nature communications

DOI

EISSN

2041-1723

ISSN

2041-1723

Publication Date

June 2022

Volume

13

Issue

1

Start / End Page

3528

Related Subject Headings

  • United Kingdom
  • Surveys and Questionnaires
  • Risk Factors
  • Post-Acute COVID-19 Syndrome
  • Longitudinal Studies
  • Humans
  • Female
  • Electronic Health Records
  • COVID-19
 

Citation

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Thompson, E. J., Williams, D. M., Walker, A. J., Mitchell, R. E., Niedzwiedz, C. L., Yang, T. C., … Steves, C. J. (2022). Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records. Nature Communications, 13(1), 3528. https://doi.org/10.1038/s41467-022-30836-0
Thompson, Ellen J., Dylan M. Williams, Alex J. Walker, Ruth E. Mitchell, Claire L. Niedzwiedz, Tiffany C. Yang, Charlotte F. Huggins, et al. “Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records.Nature Communications 13, no. 1 (June 2022): 3528. https://doi.org/10.1038/s41467-022-30836-0.
Thompson EJ, Williams DM, Walker AJ, Mitchell RE, Niedzwiedz CL, Yang TC, et al. Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records. Nature communications. 2022 Jun;13(1):3528.
Thompson, Ellen J., et al. “Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records.Nature Communications, vol. 13, no. 1, June 2022, p. 3528. Epmc, doi:10.1038/s41467-022-30836-0.
Thompson EJ, Williams DM, Walker AJ, Mitchell RE, Niedzwiedz CL, Yang TC, Huggins CF, Kwong ASF, Silverwood RJ, Di Gessa G, Bowyer RCE, Northstone K, Hou B, Green MJ, Dodgeon B, Doores KJ, Duncan EL, Williams FMK, OpenSAFELY Collaborative, Steptoe A, Porteous DJ, McEachan RRC, Tomlinson L, Goldacre B, Patalay P, Ploubidis GB, Katikireddi SV, Tilling K, Rentsch CT, Timpson NJ, Chaturvedi N, Steves CJ. Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records. Nature communications. 2022 Jun;13(1):3528.

Published In

Nature communications

DOI

EISSN

2041-1723

ISSN

2041-1723

Publication Date

June 2022

Volume

13

Issue

1

Start / End Page

3528

Related Subject Headings

  • United Kingdom
  • Surveys and Questionnaires
  • Risk Factors
  • Post-Acute COVID-19 Syndrome
  • Longitudinal Studies
  • Humans
  • Female
  • Electronic Health Records
  • COVID-19