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Metabolic programming and immune suppression in the tumor microenvironment.

Publication ,  Journal Article
Arner, EN; Rathmell, JC
Published in: Cancer cell
March 2023

Increased glucose metabolism and uptake are characteristic of many tumors and used clinically to diagnose and monitor cancer progression. In addition to cancer cells, the tumor microenvironment (TME) encompasses a wide range of stromal, innate, and adaptive immune cells. Cooperation and competition between these cell populations supports tumor proliferation, progression, metastasis, and immune evasion. Cellular heterogeneity leads to metabolic heterogeneity because metabolic programs within the tumor are dependent not only on the TME cellular composition but also on cell states, location, and nutrient availability. In addition to driving metabolic plasticity of cancer cells, altered nutrients and signals in the TME can lead to metabolic immune suppression of effector cells and promote regulatory immune cells. Here we discuss how metabolic programming of cells within the TME promotes tumor proliferation, progression, and metastasis. We also discuss how targeting metabolic heterogeneity may offer therapeutic opportunities to overcome immune suppression and augment immunotherapies.

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Published In

Cancer cell

DOI

EISSN

1878-3686

ISSN

1535-6108

Publication Date

March 2023

Volume

41

Issue

3

Start / End Page

421 / 433

Related Subject Headings

  • Tumor Microenvironment
  • Oncology & Carcinogenesis
  • Neoplasms
  • Lymphocytes
  • Immunotherapy
  • Humans
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis
  • 1109 Neurosciences
 

Citation

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ICMJE
MLA
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Arner, E. N., & Rathmell, J. C. (2023). Metabolic programming and immune suppression in the tumor microenvironment. Cancer Cell, 41(3), 421–433. https://doi.org/10.1016/j.ccell.2023.01.009
Arner, Emily N., and Jeffrey C. Rathmell. “Metabolic programming and immune suppression in the tumor microenvironment.Cancer Cell 41, no. 3 (March 2023): 421–33. https://doi.org/10.1016/j.ccell.2023.01.009.
Arner EN, Rathmell JC. Metabolic programming and immune suppression in the tumor microenvironment. Cancer cell. 2023 Mar;41(3):421–33.
Arner, Emily N., and Jeffrey C. Rathmell. “Metabolic programming and immune suppression in the tumor microenvironment.Cancer Cell, vol. 41, no. 3, Mar. 2023, pp. 421–33. Epmc, doi:10.1016/j.ccell.2023.01.009.
Arner EN, Rathmell JC. Metabolic programming and immune suppression in the tumor microenvironment. Cancer cell. 2023 Mar;41(3):421–433.
Journal cover image

Published In

Cancer cell

DOI

EISSN

1878-3686

ISSN

1535-6108

Publication Date

March 2023

Volume

41

Issue

3

Start / End Page

421 / 433

Related Subject Headings

  • Tumor Microenvironment
  • Oncology & Carcinogenesis
  • Neoplasms
  • Lymphocytes
  • Immunotherapy
  • Humans
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis
  • 1109 Neurosciences