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Adipose tissue at single-cell resolution.

Publication ,  Journal Article
Maniyadath, B; Zhang, Q; Gupta, RK; Mandrup, S
Published in: Cell Metab
March 7, 2023

Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular composition under physiological and pathophysiological conditions. The emergence of single-cell transcriptomics has rapidly transformed our understanding of the diverse array of cell types and cell states residing in adipose tissues and has provided insight into how transcriptional changes in individual cell types contribute to tissue plasticity. Here, we present a comprehensive overview of the cellular atlas of adipose tissues focusing on the biological insight gained from single-cell and single-nuclei transcriptomics of murine and human adipose tissues. We also offer our perspective on the exciting opportunities for mapping cellular transitions and crosstalk, which have been made possible by single-cell technologies.

Duke Scholars

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Published In

Cell Metab

DOI

EISSN

1932-7420

Publication Date

March 7, 2023

Volume

35

Issue

3

Start / End Page

386 / 413

Location

United States

Related Subject Headings

  • Mice
  • Humans
  • Gene Expression Profiling
  • Endocrinology & Metabolism
  • Cell Differentiation
  • Animals
  • Adipose Tissue
  • Adipogenesis
  • Adipocytes
  • 3205 Medical biochemistry and metabolomics
 

Citation

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Maniyadath, B., Zhang, Q., Gupta, R. K., & Mandrup, S. (2023). Adipose tissue at single-cell resolution. Cell Metab, 35(3), 386–413. https://doi.org/10.1016/j.cmet.2023.02.002
Maniyadath, Babukrishna, Qianbin Zhang, Rana K. Gupta, and Susanne Mandrup. “Adipose tissue at single-cell resolution.Cell Metab 35, no. 3 (March 7, 2023): 386–413. https://doi.org/10.1016/j.cmet.2023.02.002.
Maniyadath B, Zhang Q, Gupta RK, Mandrup S. Adipose tissue at single-cell resolution. Cell Metab. 2023 Mar 7;35(3):386–413.
Maniyadath, Babukrishna, et al. “Adipose tissue at single-cell resolution.Cell Metab, vol. 35, no. 3, Mar. 2023, pp. 386–413. Pubmed, doi:10.1016/j.cmet.2023.02.002.
Maniyadath B, Zhang Q, Gupta RK, Mandrup S. Adipose tissue at single-cell resolution. Cell Metab. 2023 Mar 7;35(3):386–413.
Journal cover image

Published In

Cell Metab

DOI

EISSN

1932-7420

Publication Date

March 7, 2023

Volume

35

Issue

3

Start / End Page

386 / 413

Location

United States

Related Subject Headings

  • Mice
  • Humans
  • Gene Expression Profiling
  • Endocrinology & Metabolism
  • Cell Differentiation
  • Animals
  • Adipose Tissue
  • Adipogenesis
  • Adipocytes
  • 3205 Medical biochemistry and metabolomics