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A global core outcome measurement set for snakebite clinical trials.

Publication ,  Journal Article
Abouyannis, M; Esmail, H; Hamaluba, M; Ngama, M; Mwangudzah, H; Mumba, N; Yeri, BK; Mwalukore, S; Alphan, HJ; Aggarwal, D; Alcoba, G ...
Published in: Lancet Glob Health
February 2023

Snakebite clinical trials have often used heterogeneous outcome measures and there is an urgent need for standardisation. A globally representative group of key stakeholders came together to reach consensus on a globally relevant set of core outcome measurements. Outcome domains and outcome measurement instruments were identified through searching the literature and a systematic review of snakebite clinical trials. Outcome domains were shortlisted by use of a questionnaire and consensus was reached among stakeholders and the patient group through facilitated discussions and voting. Five universal core outcome measures should be included in all future snakebite clinical trials-mortality, WHO disability assessment scale, patient-specific functional scale, acute allergic reaction by Brown criteria, and serum sickness by formal criteria. Additional syndrome-specific core outcome measures should be used depending on the biting species. This core outcome measurement set provides global standardisation, supports the priorities of patients and clinicians, enables meta-analysis, and is appropriate for use in low-income and middle-income settings.

Duke Scholars

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Published In

Lancet Glob Health

DOI

EISSN

2214-109X

Publication Date

February 2023

Volume

11

Issue

2

Start / End Page

e296 / e300

Location

England

Related Subject Headings

  • Treatment Outcome
  • Surveys and Questionnaires
  • Snake Bites
  • Outcome Assessment, Health Care
  • Humans
  • Global Health
  • Consensus
  • Clinical Trials as Topic
  • 4206 Public health
  • 4203 Health services and systems
 

Citation

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Abouyannis, M., Esmail, H., Hamaluba, M., Ngama, M., Mwangudzah, H., Mumba, N., … Snakebite Global Core Outcome Set Study Group, . (2023). A global core outcome measurement set for snakebite clinical trials. Lancet Glob Health, 11(2), e296–e300. https://doi.org/10.1016/S2214-109X(22)00479-X
Abouyannis, Michael, Hanif Esmail, Mainga Hamaluba, Mwanajuma Ngama, Hope Mwangudzah, Noni Mumba, Betty K. Yeri, et al. “A global core outcome measurement set for snakebite clinical trials.Lancet Glob Health 11, no. 2 (February 2023): e296–300. https://doi.org/10.1016/S2214-109X(22)00479-X.
Abouyannis M, Esmail H, Hamaluba M, Ngama M, Mwangudzah H, Mumba N, et al. A global core outcome measurement set for snakebite clinical trials. Lancet Glob Health. 2023 Feb;11(2):e296–300.
Abouyannis, Michael, et al. “A global core outcome measurement set for snakebite clinical trials.Lancet Glob Health, vol. 11, no. 2, Feb. 2023, pp. e296–300. Pubmed, doi:10.1016/S2214-109X(22)00479-X.
Abouyannis M, Esmail H, Hamaluba M, Ngama M, Mwangudzah H, Mumba N, Yeri BK, Mwalukore S, Alphan HJ, Aggarwal D, Alcoba G, Cammack N, Chippaux J-P, Coldiron ME, Gutiérrez JM, Habib AG, Harrison RA, Isbister GK, Lavonas EJ, Martins D, Ribeiro I, Watson JA, Williams DJ, Casewell NR, Walker SA, Lalloo DG, Snakebite Global Core Outcome Set Study Group. A global core outcome measurement set for snakebite clinical trials. Lancet Glob Health. 2023 Feb;11(2):e296–e300.
Journal cover image

Published In

Lancet Glob Health

DOI

EISSN

2214-109X

Publication Date

February 2023

Volume

11

Issue

2

Start / End Page

e296 / e300

Location

England

Related Subject Headings

  • Treatment Outcome
  • Surveys and Questionnaires
  • Snake Bites
  • Outcome Assessment, Health Care
  • Humans
  • Global Health
  • Consensus
  • Clinical Trials as Topic
  • 4206 Public health
  • 4203 Health services and systems