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Metabolic Reprogramming and Potential Therapeutic Targets in Lymphoma.

Publication ,  Journal Article
Pang, Y; Lu, T; Xu-Monette, ZY; Young, KH
Published in: Int J Mol Sci
March 13, 2023

Lymphoma is a heterogeneous group of diseases that often require their metabolism program to fulfill the demand of cell proliferation. Features of metabolism in lymphoma cells include high glucose uptake, deregulated expression of enzymes related to glycolysis, dual capacity for glycolytic and oxidative metabolism, elevated glutamine metabolism, and fatty acid synthesis. These aberrant metabolic changes lead to tumorigenesis, disease progression, and resistance to lymphoma chemotherapy. This metabolic reprogramming, including glucose, nucleic acid, fatty acid, and amino acid metabolism, is a dynamic process caused not only by genetic and epigenetic changes, but also by changes in the microenvironment affected by viral infections. Notably, some critical metabolic enzymes and metabolites may play vital roles in lymphomagenesis and progression. Recent studies have uncovered that metabolic pathways might have clinical impacts on the diagnosis, characterization, and treatment of lymphoma subtypes. However, determining the clinical relevance of biomarkers and therapeutic targets related to lymphoma metabolism is still challenging. In this review, we systematically summarize current studies on metabolism reprogramming in lymphoma, and we mainly focus on disorders of glucose, amino acids, and lipid metabolisms, as well as dysregulation of molecules in metabolic pathways, oncometabolites, and potential metabolic biomarkers. We then discuss strategies directly or indirectly for those potential therapeutic targets. Finally, we prospect the future directions of lymphoma treatment on metabolic reprogramming.

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Published In

Int J Mol Sci

DOI

EISSN

1422-0067

Publication Date

March 13, 2023

Volume

24

Issue

6

Location

Switzerland

Related Subject Headings

  • Tumor Microenvironment
  • Metabolic Networks and Pathways
  • Lymphoma
  • Humans
  • Glycolysis
  • Glucose
  • Fatty Acids
  • Chemical Physics
  • 3404 Medicinal and biomolecular chemistry
  • 3107 Microbiology
 

Citation

APA
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ICMJE
MLA
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Pang, Y., Lu, T., Xu-Monette, Z. Y., & Young, K. H. (2023). Metabolic Reprogramming and Potential Therapeutic Targets in Lymphoma. Int J Mol Sci, 24(6). https://doi.org/10.3390/ijms24065493
Pang, Yuyang, Tingxun Lu, Zijun Y. Xu-Monette, and Ken H. Young. “Metabolic Reprogramming and Potential Therapeutic Targets in Lymphoma.Int J Mol Sci 24, no. 6 (March 13, 2023). https://doi.org/10.3390/ijms24065493.
Pang Y, Lu T, Xu-Monette ZY, Young KH. Metabolic Reprogramming and Potential Therapeutic Targets in Lymphoma. Int J Mol Sci. 2023 Mar 13;24(6).
Pang, Yuyang, et al. “Metabolic Reprogramming and Potential Therapeutic Targets in Lymphoma.Int J Mol Sci, vol. 24, no. 6, Mar. 2023. Pubmed, doi:10.3390/ijms24065493.
Pang Y, Lu T, Xu-Monette ZY, Young KH. Metabolic Reprogramming and Potential Therapeutic Targets in Lymphoma. Int J Mol Sci. 2023 Mar 13;24(6).

Published In

Int J Mol Sci

DOI

EISSN

1422-0067

Publication Date

March 13, 2023

Volume

24

Issue

6

Location

Switzerland

Related Subject Headings

  • Tumor Microenvironment
  • Metabolic Networks and Pathways
  • Lymphoma
  • Humans
  • Glycolysis
  • Glucose
  • Fatty Acids
  • Chemical Physics
  • 3404 Medicinal and biomolecular chemistry
  • 3107 Microbiology