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Polarity in skin development and cancer.

Publication ,  Chapter
Prado-Mantilla, A; Lechler, T
2023

The epidermis is a stratified squamous epithelium that forms the outermost layer of the skin. Its primary function is to act as a barrier, keeping pathogens and toxins out and moisture in. This physiological role has necessitated major differences in the organization and polarity of the tissue as compared to simple epithelia. We discuss four aspects of polarity in the epidermis - the distinctive polarities of basal progenitor cells as well as differentiated granular cells, the polarity of adhesions and the cytoskeleton across the tissue as keratinocytes differentiate, and the planar cell polarity of the tissue. These distinctive polarities are essential for the morphogenesis and the function of the epidermis and have also been implicated in regulating tumor formation.

Duke Scholars

DOI

Publication Date

2023

Volume

154

Start / End Page

317 / 336

Related Subject Headings

  • Skin
  • Neoplasms
  • Humans
  • Epithelium
  • Epidermis
  • Epidermal Cells
  • Developmental Biology
  • Cell Polarity
  • 3102 Bioinformatics and computational biology
  • 1114 Paediatrics and Reproductive Medicine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Prado-Mantilla, A., & Lechler, T. (2023). Polarity in skin development and cancer. (Vol. 154, pp. 317–336). https://doi.org/10.1016/bs.ctdb.2023.02.003
Prado-Mantilla, Alexandra, and Terry Lechler. “Polarity in skin development and cancer.,” 154:317–36, 2023. https://doi.org/10.1016/bs.ctdb.2023.02.003.
Prado-Mantilla A, Lechler T. Polarity in skin development and cancer. In 2023. p. 317–36.
Prado-Mantilla, Alexandra, and Terry Lechler. Polarity in skin development and cancer. Vol. 154, 2023, pp. 317–36. Pubmed, doi:10.1016/bs.ctdb.2023.02.003.
Prado-Mantilla A, Lechler T. Polarity in skin development and cancer. 2023. p. 317–336.

DOI

Publication Date

2023

Volume

154

Start / End Page

317 / 336

Related Subject Headings

  • Skin
  • Neoplasms
  • Humans
  • Epithelium
  • Epidermis
  • Epidermal Cells
  • Developmental Biology
  • Cell Polarity
  • 3102 Bioinformatics and computational biology
  • 1114 Paediatrics and Reproductive Medicine