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Epidemiology and Impact of Campylobacter Infection in Children in 8 Low-Resource Settings: Results From the MAL-ED Study.

Publication ,  Journal Article
Amour, C; Gratz, J; Mduma, E; Svensen, E; Rogawski, ET; McGrath, M; Seidman, JC; McCormick, BJJ; Shrestha, S; Samie, A; Mahfuz, M; Qureshi, S ...
Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
November 2016

Enteropathogen infections have been associated with enteric dysfunction and impaired growth in children in low-resource settings. In a multisite birth cohort study (MAL-ED), we describe the epidemiology and impact of Campylobacter infection in the first 2 years of life.Children were actively followed up until 24 months of age. Diarrheal and nondiarrheal stool samples were collected and tested by enzyme immunoassay for Campylobacter Stool and blood samples were assayed for markers of intestinal permeability and inflammation.A total of 1892 children had 7601 diarrheal and 26 267 nondiarrheal stool samples tested for Campylobacter We describe a high prevalence of infection, with most children (n = 1606; 84.9%) having a Campylobacter-positive stool sample by 1 year of age. Factors associated with a reduced risk of Campylobacter detection included exclusive breastfeeding (risk ratio, 0.57; 95% confidence interval, .47-.67), treatment of drinking water (0.76; 0.70-0.83), access to an improved latrine (0.89; 0.82-0.97), and recent macrolide antibiotic use (0.68; 0.63-0.74). A high Campylobacter burden was associated with a lower length-for-age Z score at 24 months (-1.82; 95% confidence interval, -1.94 to -1.70) compared with a low burden (-1.49; -1.60 to -1.38). This association was robust to confounders and consistent across sites. Campylobacter infection was also associated with increased intestinal permeability and intestinal and systemic inflammation.Campylobacter was prevalent across diverse settings and associated with growth shortfalls. Promotion of exclusive breastfeeding, drinking water treatment, improved latrines, and targeted antibiotic treatment may reduce the burden of Campylobacter infection and improve growth in children in these settings.

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Published In

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

DOI

EISSN

1537-6591

ISSN

1058-4838

Publication Date

November 2016

Volume

63

Issue

9

Start / End Page

1171 / 1179

Related Subject Headings

  • Risk Factors
  • Prospective Studies
  • Prevalence
  • Microbiology
  • Male
  • Infant, Newborn
  • Infant
  • Humans
  • Gastroenteritis
  • Follow-Up Studies
 

Citation

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Chicago
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MLA
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Amour, C., Gratz, J., Mduma, E., Svensen, E., Rogawski, E. T., McGrath, M., … Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project (MAL-ED) Network Investigators, . (2016). Epidemiology and Impact of Campylobacter Infection in Children in 8 Low-Resource Settings: Results From the MAL-ED Study. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 63(9), 1171–1179. https://doi.org/10.1093/cid/ciw542
Amour, Caroline, Jean Gratz, Estomih Mduma, Erling Svensen, Elizabeth T. Rogawski, Monica McGrath, Jessica C. Seidman, et al. “Epidemiology and Impact of Campylobacter Infection in Children in 8 Low-Resource Settings: Results From the MAL-ED Study.Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America 63, no. 9 (November 2016): 1171–79. https://doi.org/10.1093/cid/ciw542.
Amour C, Gratz J, Mduma E, Svensen E, Rogawski ET, McGrath M, et al. Epidemiology and Impact of Campylobacter Infection in Children in 8 Low-Resource Settings: Results From the MAL-ED Study. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2016 Nov;63(9):1171–9.
Amour, Caroline, et al. “Epidemiology and Impact of Campylobacter Infection in Children in 8 Low-Resource Settings: Results From the MAL-ED Study.Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, vol. 63, no. 9, Nov. 2016, pp. 1171–79. Epmc, doi:10.1093/cid/ciw542.
Amour C, Gratz J, Mduma E, Svensen E, Rogawski ET, McGrath M, Seidman JC, McCormick BJJ, Shrestha S, Samie A, Mahfuz M, Qureshi S, Hotwani A, Babji S, Trigoso DR, Lima AAM, Bodhidatta L, Bessong P, Ahmed T, Shakoor S, Kang G, Kosek M, Guerrant RL, Lang D, Gottlieb M, Houpt ER, Platts-Mills JA, Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project (MAL-ED) Network Investigators. Epidemiology and Impact of Campylobacter Infection in Children in 8 Low-Resource Settings: Results From the MAL-ED Study. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2016 Nov;63(9):1171–1179.
Journal cover image

Published In

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

DOI

EISSN

1537-6591

ISSN

1058-4838

Publication Date

November 2016

Volume

63

Issue

9

Start / End Page

1171 / 1179

Related Subject Headings

  • Risk Factors
  • Prospective Studies
  • Prevalence
  • Microbiology
  • Male
  • Infant, Newborn
  • Infant
  • Humans
  • Gastroenteritis
  • Follow-Up Studies