Skip to main content
Journal cover image

Correlation of putative iron content as represented by changes in R2* and phase with age in deep gray matter of healthy adults.

Publication ,  Journal Article
Haacke, EM; Miao, Y; Liu, M; Habib, CA; Katkuri, Y; Liu, T; Yang, Z; Lang, Z; Hu, J; Wu, J
Published in: Journal of magnetic resonance imaging : JMRI
September 2010

To establish a correlation between putative iron content using susceptibility weighted imaging (SWI) phase and T2* weighted magnitude values in the basal ganglia and the thalamus as a function of age in healthy human brains.One hundred healthy adults (range, 20-69 years; mean, 43 years) were evaluated for this study using a gradient echo sequence. The original magnitude and high pass filtered phase data were analyzed as proxy variables for iron content in the substantia nigra, red nucleus, globus pallidus, putamen, caudate nucleus, thalamus, and pulvinar thalamus. Each structure was broken into two parts, a high iron content region and a low iron content region.Both magnitude and phase data showed an increase in putative iron content with age. However, the high iron content region revealed two new pieces of information: both the average iron content per pixel and the area of high iron increased with age. Furthermore, significant increase in iron uptake as a function of age was found past the age of 40.A two region of interest analysis of iron is a much more sensitive means to evaluate iron content change over time. Contrary to the current belief that iron content increases level off with age, the putative iron deposition in the high iron content region is seen to increase with age.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Journal of magnetic resonance imaging : JMRI

DOI

EISSN

1522-2586

ISSN

1053-1807

Publication Date

September 2010

Volume

32

Issue

3

Start / End Page

561 / 576

Related Subject Headings

  • Young Adult
  • Thalamus
  • Substantia Nigra
  • Regression Analysis
  • Reference Values
  • Red Nucleus
  • Putamen
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Haacke, E. M., Miao, Y., Liu, M., Habib, C. A., Katkuri, Y., Liu, T., … Wu, J. (2010). Correlation of putative iron content as represented by changes in R2* and phase with age in deep gray matter of healthy adults. Journal of Magnetic Resonance Imaging : JMRI, 32(3), 561–576. https://doi.org/10.1002/jmri.22293
Haacke, E Mark, Yanwei Miao, Manju Liu, Charbel A. Habib, Yashwanth Katkuri, Ting Liu, Zhihong Yang, Zhijin Lang, Jiani Hu, and Jianlin Wu. “Correlation of putative iron content as represented by changes in R2* and phase with age in deep gray matter of healthy adults.Journal of Magnetic Resonance Imaging : JMRI 32, no. 3 (September 2010): 561–76. https://doi.org/10.1002/jmri.22293.
Haacke EM, Miao Y, Liu M, Habib CA, Katkuri Y, Liu T, et al. Correlation of putative iron content as represented by changes in R2* and phase with age in deep gray matter of healthy adults. Journal of magnetic resonance imaging : JMRI. 2010 Sep;32(3):561–76.
Haacke, E. Mark, et al. “Correlation of putative iron content as represented by changes in R2* and phase with age in deep gray matter of healthy adults.Journal of Magnetic Resonance Imaging : JMRI, vol. 32, no. 3, Sept. 2010, pp. 561–76. Epmc, doi:10.1002/jmri.22293.
Haacke EM, Miao Y, Liu M, Habib CA, Katkuri Y, Liu T, Yang Z, Lang Z, Hu J, Wu J. Correlation of putative iron content as represented by changes in R2* and phase with age in deep gray matter of healthy adults. Journal of magnetic resonance imaging : JMRI. 2010 Sep;32(3):561–576.
Journal cover image

Published In

Journal of magnetic resonance imaging : JMRI

DOI

EISSN

1522-2586

ISSN

1053-1807

Publication Date

September 2010

Volume

32

Issue

3

Start / End Page

561 / 576

Related Subject Headings

  • Young Adult
  • Thalamus
  • Substantia Nigra
  • Regression Analysis
  • Reference Values
  • Red Nucleus
  • Putamen
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male