Developmental arrest of angioblastic lineage initiates tumorigenesis in von Hippel-Lindau disease.
Publication
, Journal Article
Vortmeyer, AO; Frank, S; Jeong, S-Y; Yuan, K; Ikejiri, B; Lee, Y-S; Bhowmick, D; Lonser, RR; Smith, R; Rodgers, G; Oldfield, EH; Zhuang, Z
Published in: Cancer Res
November 1, 2003
The nature of the cell responsible for von Hippel-Lindau (VHL) disease-associated tumor formation has been controversial for decades. We demonstrate that VHL disease-associated central nervous system tumors are composed of developmentally arrested angioblasts that coexpress erythropoietin (Epo) and Epo receptor. The angioblasts are capable of differentiating into RBCs via formation of blood islands with extramedullary hematopoiesis. Because of VHL deficiency, Epo receptor-expressing, developmentally arrested angioblasts simultaneously coexpress Epo, which may represent a crucial pathogenetic step in tumor formation.
Duke Scholars
Published In
Cancer Res
ISSN
0008-5472
Publication Date
November 1, 2003
Volume
63
Issue
21
Start / End Page
7051 / 7055
Location
United States
Related Subject Headings
- von Hippel-Lindau Disease
- Receptors, Erythropoietin
- Oncology & Carcinogenesis
- Immunohistochemistry
- Humans
- Hematopoiesis, Extramedullary
- Hemangioblastoma
- Erythropoietin
- Cerebellar Neoplasms
- 3211 Oncology and carcinogenesis
Citation
APA
Chicago
ICMJE
MLA
NLM
Vortmeyer, A. O., Frank, S., Jeong, S.-Y., Yuan, K., Ikejiri, B., Lee, Y.-S., … Zhuang, Z. (2003). Developmental arrest of angioblastic lineage initiates tumorigenesis in von Hippel-Lindau disease. Cancer Res, 63(21), 7051–7055.
Vortmeyer, Alexander O., Stephan Frank, Seon-Yong Jeong, Kristy Yuan, Barbara Ikejiri, Youn-Soo Lee, Deb Bhowmick, et al. “Developmental arrest of angioblastic lineage initiates tumorigenesis in von Hippel-Lindau disease.” Cancer Res 63, no. 21 (November 1, 2003): 7051–55.
Vortmeyer AO, Frank S, Jeong S-Y, Yuan K, Ikejiri B, Lee Y-S, et al. Developmental arrest of angioblastic lineage initiates tumorigenesis in von Hippel-Lindau disease. Cancer Res. 2003 Nov 1;63(21):7051–5.
Vortmeyer, Alexander O., et al. “Developmental arrest of angioblastic lineage initiates tumorigenesis in von Hippel-Lindau disease.” Cancer Res, vol. 63, no. 21, Nov. 2003, pp. 7051–55.
Vortmeyer AO, Frank S, Jeong S-Y, Yuan K, Ikejiri B, Lee Y-S, Bhowmick D, Lonser RR, Smith R, Rodgers G, Oldfield EH, Zhuang Z. Developmental arrest of angioblastic lineage initiates tumorigenesis in von Hippel-Lindau disease. Cancer Res. 2003 Nov 1;63(21):7051–7055.
Published In
Cancer Res
ISSN
0008-5472
Publication Date
November 1, 2003
Volume
63
Issue
21
Start / End Page
7051 / 7055
Location
United States
Related Subject Headings
- von Hippel-Lindau Disease
- Receptors, Erythropoietin
- Oncology & Carcinogenesis
- Immunohistochemistry
- Humans
- Hematopoiesis, Extramedullary
- Hemangioblastoma
- Erythropoietin
- Cerebellar Neoplasms
- 3211 Oncology and carcinogenesis