Viewing both sides of the coin for infectious disease diagnosis.
Publication
, Journal Article
Strouts, FR; McAllister, LB; Tsalik, EL
Published in: J Clin Invest
April 17, 2023
Optimal management of lower respiratory tract infection relies on distinguishing infectious from noninfectious etiologies and identifying the microbiologic cause if applicable. This process is complicated by overlapping clinical symptoms and the colonizing lung microbiota. In a recent issue of the JCI, Mick, Tsitsiklis, and colleagues apply RNA-Seq to tracheal aspirates from critically ill children and demonstrate how integration of the host response with microbial identification results in a harmonious and accurate diagnostic classifier. Though promising, there are numerous barriers to realizing a combined host and pathogen diagnostic.
Duke Scholars
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Published In
J Clin Invest
DOI
EISSN
1558-8238
Publication Date
April 17, 2023
Volume
133
Issue
8
Location
United States
Related Subject Headings
- Respiratory Tract Infections
- Microbiota
- Lung
- Immunology
- Humans
- Exome Sequencing
- Communicable Diseases
- Child
- 42 Health sciences
- 32 Biomedical and clinical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Strouts, F. R., McAllister, L. B., & Tsalik, E. L. (2023). Viewing both sides of the coin for infectious disease diagnosis. J Clin Invest, 133(8). https://doi.org/10.1172/JCI169242
Strouts, Fiona R., Linda B. McAllister, and Ephraim L. Tsalik. “Viewing both sides of the coin for infectious disease diagnosis.” J Clin Invest 133, no. 8 (April 17, 2023). https://doi.org/10.1172/JCI169242.
Strouts FR, McAllister LB, Tsalik EL. Viewing both sides of the coin for infectious disease diagnosis. J Clin Invest. 2023 Apr 17;133(8).
Strouts, Fiona R., et al. “Viewing both sides of the coin for infectious disease diagnosis.” J Clin Invest, vol. 133, no. 8, Apr. 2023. Pubmed, doi:10.1172/JCI169242.
Strouts FR, McAllister LB, Tsalik EL. Viewing both sides of the coin for infectious disease diagnosis. J Clin Invest. 2023 Apr 17;133(8).
Published In
J Clin Invest
DOI
EISSN
1558-8238
Publication Date
April 17, 2023
Volume
133
Issue
8
Location
United States
Related Subject Headings
- Respiratory Tract Infections
- Microbiota
- Lung
- Immunology
- Humans
- Exome Sequencing
- Communicable Diseases
- Child
- 42 Health sciences
- 32 Biomedical and clinical sciences