Skip to main content
Journal cover image

Proton density water fraction as a reproducible MR-based measurement of breast density.

Publication ,  Journal Article
Henze Bancroft, LC; Strigel, RM; Macdonald, EB; Longhurst, C; Johnson, J; Hernando, D; Reeder, SB
Published in: Magnetic resonance in medicine
April 2022

To introduce proton density water fraction (PDWF) as a confounder-corrected (CC) MR-based biomarker of mammographic breast density, a known risk factor for breast cancer.Chemical shift encoded (CSE) MR images were acquired using a low flip angle to provide proton density contrast from multiple echo times. Fat and water images, corrected for known biases, were produced by a six-echo CC CSE-MRI algorithm. Fibroglandular tissue (FGT) volume was calculated from whole-breast segmented PDWF maps at 1.5T and 3T. The method was evaluated in (1) a physical fat-water phantom and (2) normal volunteers. Results from two- and three-echo CSE-MRI methods were included for comparison.Six-echo CC-CSE-MRI produced unbiased estimates of the total water volume in the phantom (mean bias 3.3%) and was reproducible across protocol changes (repeatability coefficient [RC] = 14.8 cm3 and 13.97 cm3 at 1.5T and 3.0T, respectively) and field strengths (RC = 51.7 cm3 ) in volunteers, while the two- and three-echo CSE-MRI approaches produced biased results in phantoms (mean bias 30.7% and 10.4%) that was less reproducible across field strengths in volunteers (RC = 82.3 cm3 and 126.3 cm3 ). Significant differences in measured FGT volume were found between the six-echo CC-CSE-MRI and the two- and three-echo CSE-MRI approaches (p = 0.002 and p = 0.001, respectively).The use of six-echo CC-CSE-MRI to create unbiased PDWF maps that reproducibly quantify FGT in the breast is demonstrated. Further studies are needed to correlate this quantitative MR biomarker for breast density with mammography and overall risk for breast cancer.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Magnetic resonance in medicine

DOI

EISSN

1522-2594

ISSN

0740-3194

Publication Date

April 2022

Volume

87

Issue

4

Start / End Page

1742 / 1757

Related Subject Headings

  • Water
  • Reproducibility of Results
  • Protons
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Humans
  • Breast Density
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Henze Bancroft, L. C., Strigel, R. M., Macdonald, E. B., Longhurst, C., Johnson, J., Hernando, D., & Reeder, S. B. (2022). Proton density water fraction as a reproducible MR-based measurement of breast density. Magnetic Resonance in Medicine, 87(4), 1742–1757. https://doi.org/10.1002/mrm.29076
Henze Bancroft, Leah C., Roberta M. Strigel, Erin B. Macdonald, Colin Longhurst, Jacob Johnson, Diego Hernando, and Scott B. Reeder. “Proton density water fraction as a reproducible MR-based measurement of breast density.Magnetic Resonance in Medicine 87, no. 4 (April 2022): 1742–57. https://doi.org/10.1002/mrm.29076.
Henze Bancroft LC, Strigel RM, Macdonald EB, Longhurst C, Johnson J, Hernando D, et al. Proton density water fraction as a reproducible MR-based measurement of breast density. Magnetic resonance in medicine. 2022 Apr;87(4):1742–57.
Henze Bancroft, Leah C., et al. “Proton density water fraction as a reproducible MR-based measurement of breast density.Magnetic Resonance in Medicine, vol. 87, no. 4, Apr. 2022, pp. 1742–57. Epmc, doi:10.1002/mrm.29076.
Henze Bancroft LC, Strigel RM, Macdonald EB, Longhurst C, Johnson J, Hernando D, Reeder SB. Proton density water fraction as a reproducible MR-based measurement of breast density. Magnetic resonance in medicine. 2022 Apr;87(4):1742–1757.
Journal cover image

Published In

Magnetic resonance in medicine

DOI

EISSN

1522-2594

ISSN

0740-3194

Publication Date

April 2022

Volume

87

Issue

4

Start / End Page

1742 / 1757

Related Subject Headings

  • Water
  • Reproducibility of Results
  • Protons
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Humans
  • Breast Density
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering