Reduced expression of TGF beta1RII in agnogenic myeloid metaplasia is not due to mutation or methylation.
Publication
, Journal Article
Hemavathy, KC; Chang, TH; Zhang, H; Charles, W; Goldberg, A; Aithal, S; Novetsky, AD; Wang, JC
Published in: Leuk Res
January 2006
Agnogenic myeloid metaplasia (AMM) is characterized by bone marrow fibrosis and enhanced proliferation of megakaryocytes and CD34+ cells. We have analyzed the factors that could lead to reduced expression of TGF beta1RII in CD34+ cells of AMM patients. Our results demonstrate absence of mutations in the coding region and the promoter of this gene and absence of CpG methylation of its promoter in AMM patients. Further studies on transcriptional regulation of TGF beta1RII involving its cis-regulatory elements, the interacting transcription factors and their association with HDAC will provide valuable information on the pathogenesis of AMM and are under current investigation.
Duke Scholars
Published In
Leuk Res
DOI
ISSN
0145-2126
Publication Date
January 2006
Volume
30
Issue
1
Start / End Page
47 / 53
Location
England
Related Subject Headings
- Transcription, Genetic
- Transcription Factors
- Receptors, Transforming Growth Factor beta
- Receptor, Transforming Growth Factor-beta Type II
- Protein Serine-Threonine Kinases
- Promoter Regions, Genetic
- Primary Myelofibrosis
- Mutation
- Megakaryocytes
- Male
Citation
APA
Chicago
ICMJE
MLA
NLM
Hemavathy, K. C., Chang, T. H., Zhang, H., Charles, W., Goldberg, A., Aithal, S., … Wang, J. C. (2006). Reduced expression of TGF beta1RII in agnogenic myeloid metaplasia is not due to mutation or methylation. Leuk Res, 30(1), 47–53. https://doi.org/10.1016/j.leukres.2005.06.010
Hemavathy, Kirugaval C., Tsong H. Chang, Haowei Zhang, William Charles, Amit Goldberg, Sramila Aithal, Allan D. Novetsky, and Jen C. Wang. “Reduced expression of TGF beta1RII in agnogenic myeloid metaplasia is not due to mutation or methylation.” Leuk Res 30, no. 1 (January 2006): 47–53. https://doi.org/10.1016/j.leukres.2005.06.010.
Hemavathy KC, Chang TH, Zhang H, Charles W, Goldberg A, Aithal S, et al. Reduced expression of TGF beta1RII in agnogenic myeloid metaplasia is not due to mutation or methylation. Leuk Res. 2006 Jan;30(1):47–53.
Hemavathy, Kirugaval C., et al. “Reduced expression of TGF beta1RII in agnogenic myeloid metaplasia is not due to mutation or methylation.” Leuk Res, vol. 30, no. 1, Jan. 2006, pp. 47–53. Pubmed, doi:10.1016/j.leukres.2005.06.010.
Hemavathy KC, Chang TH, Zhang H, Charles W, Goldberg A, Aithal S, Novetsky AD, Wang JC. Reduced expression of TGF beta1RII in agnogenic myeloid metaplasia is not due to mutation or methylation. Leuk Res. 2006 Jan;30(1):47–53.
Published In
Leuk Res
DOI
ISSN
0145-2126
Publication Date
January 2006
Volume
30
Issue
1
Start / End Page
47 / 53
Location
England
Related Subject Headings
- Transcription, Genetic
- Transcription Factors
- Receptors, Transforming Growth Factor beta
- Receptor, Transforming Growth Factor-beta Type II
- Protein Serine-Threonine Kinases
- Promoter Regions, Genetic
- Primary Myelofibrosis
- Mutation
- Megakaryocytes
- Male