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A cyclosporine-based immunosuppressive regimen may be better than tacrolimus for long-term liver allograft survival in recipients transplanted for hepatitis C.

Publication ,  Journal Article
Rayhill, SC; Barbeito, R; Katz, D; Voigt, M; Labrecque, D; Kirby, P; Miller, R; Stolpen, A; Wu, Y; Schmidt, W
Published in: Transplant Proc
December 2006

UNLABELLED: Rapid recurrence of severe hepatitis C (HCV) after liver transplantation is a major barrier to survival of the transplanted liver. While cyclosporine (CsA) in vitro has been shown to suppress HCV replication, an effect is not seen with tacrolimus (Tac). Evidence is inconsistent whether or how this translates to clinical practice. To expand the evidence on this issue, we analyzed graft survival and histological outcomes after liver transplantation for HCV hepatitis. METHODS: Using our longitudinal database (1991 onward) graft outcomes for all liver transplant recipients with HCV were evaluated (105 grafts in 97 patients). Severe activity, severe fibrosis, and graft survival were analyzed. All liver biopsies were scored (blinded) according to the Ludwig scale. Immunosuppression was based on prednisone and a calcineurin inhibitor (Tac n = 89, 85%; CsA n = 15, 14%). Comparisons of outcomes using CsA versus Tac therapy were done using survival analysis via the log-rank test. RESULTS: Graft survival was significantly better in the CsA group. Although there was no apparent difference in severe activity (grade 2), there was a statistically significant difference in graft survival without fibrosing cholestatic hepatitis (P = .01) and a trend toward a difference in fibrosis-free survival (P = 0.1). The rate of sustained response to antiviral therapy was twice as high in the CsA group, 50% versus 22% (P = 0.16; NS). CONCLUSIONS: Graft survival in liver transplant recipients with HCV may be greater with CsA-based immunosuppression. There may also be a lower rate of fibrosing cholestatic hepatitis in this group.

Duke Scholars

Published In

Transplant Proc

DOI

ISSN

0041-1345

Publication Date

December 2006

Volume

38

Issue

10

Start / End Page

3625 / 3628

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Homologous
  • Tacrolimus
  • Retrospective Studies
  • Mycophenolic Acid
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Liver Transplantation
  • Immunosuppressive Agents
 

Citation

APA
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MLA
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Rayhill, S. C., Barbeito, R., Katz, D., Voigt, M., Labrecque, D., Kirby, P., … Schmidt, W. (2006). A cyclosporine-based immunosuppressive regimen may be better than tacrolimus for long-term liver allograft survival in recipients transplanted for hepatitis C. Transplant Proc, 38(10), 3625–3628. https://doi.org/10.1016/j.transproceed.2006.10.040
Rayhill, S. C., R. Barbeito, D. Katz, M. Voigt, D. Labrecque, P. Kirby, R. Miller, A. Stolpen, Y. Wu, and W. Schmidt. “A cyclosporine-based immunosuppressive regimen may be better than tacrolimus for long-term liver allograft survival in recipients transplanted for hepatitis C.Transplant Proc 38, no. 10 (December 2006): 3625–28. https://doi.org/10.1016/j.transproceed.2006.10.040.
Rayhill SC, Barbeito R, Katz D, Voigt M, Labrecque D, Kirby P, et al. A cyclosporine-based immunosuppressive regimen may be better than tacrolimus for long-term liver allograft survival in recipients transplanted for hepatitis C. Transplant Proc. 2006 Dec;38(10):3625–8.
Rayhill, S. C., et al. “A cyclosporine-based immunosuppressive regimen may be better than tacrolimus for long-term liver allograft survival in recipients transplanted for hepatitis C.Transplant Proc, vol. 38, no. 10, Dec. 2006, pp. 3625–28. Pubmed, doi:10.1016/j.transproceed.2006.10.040.
Rayhill SC, Barbeito R, Katz D, Voigt M, Labrecque D, Kirby P, Miller R, Stolpen A, Wu Y, Schmidt W. A cyclosporine-based immunosuppressive regimen may be better than tacrolimus for long-term liver allograft survival in recipients transplanted for hepatitis C. Transplant Proc. 2006 Dec;38(10):3625–3628.
Journal cover image

Published In

Transplant Proc

DOI

ISSN

0041-1345

Publication Date

December 2006

Volume

38

Issue

10

Start / End Page

3625 / 3628

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Homologous
  • Tacrolimus
  • Retrospective Studies
  • Mycophenolic Acid
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Liver Transplantation
  • Immunosuppressive Agents