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Altered pigment epithelium-derived factor and vascular endothelial growth factor levels in lymphangioma pathogenesis and clinical recurrence.

Publication ,  Journal Article
Sidle, DM; Maddalozzo, J; Meier, JD; Cornwell, M; Stellmach, V; Crawford, SE
Published in: Arch Otolaryngol Head Neck Surg
November 2005

OBJECTIVE: To determine the role of angiogenesis in the clinical behavior and pathogenesis of lymphangioma tumors. DESIGN: A retrospective study. Median follow-up period was 44.5 months. SETTING: Children's Memorial Hospital, Chicago, Ill. PATIENTS: Tumor specimens from 12 pediatric patients who underwent surgical excision of cervicofacial lymphangioma were examined for expression of angiogenic inducer vascular endothelial growth factor (VEGF) and angiogenic inhibitor pigment epithelium-derived factor (PEDF) using immunohistochemical analysis. Specimens were divided into recurrent and nonrecurrent tumors based on clinical information. MAIN OUTCOME MEASURES: Staining patterns of VEGF and PEDF were evaluated in lymphangioma specimens. Staining patterns were then compared in both recurrent and nonrecurrent groups and graded in a blinded fashion. Histological evidence of increased angiogenesis including microvascular density, stromal fibrosis, and inflammation were graded in each group and correlated with recurrence. RESULTS: Lymphangioma specimens demonstrated histological evidence of increased angiogenic activity including multiple areas of increased VEGF staining combined with little PEDF staining. Sex, age at onset, or tumor location did not correlate with recurrence. Furthermore, recurrent specimens had increased histological evidence of angiogenesis as well as increased VEGF and decreased PEDF activity compared with nonrecurrent lesions. CONCLUSIONS: Lymphangiomas exhibit tumorlike pathogenesis owing to the high expression of angiogenic inducers compared with the low expression of inhibitors. Recurrence may be influenced by this imbalance of angiogenic mediators. Further research with antiangiogenic therapy using agents such as PEDF analogues or anti-VEGF receptor antibodies is indicated because they may stabilize or suppress the growth of these neoplasms.

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Published In

Arch Otolaryngol Head Neck Surg

DOI

ISSN

0886-4470

Publication Date

November 2005

Volume

131

Issue

11

Start / End Page

990 / 995

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Statistics as Topic
  • Serpins
  • Retrospective Studies
  • Protease Inhibitors
  • Otorhinolaryngology
  • Nerve Growth Factors
  • Neoplasm Recurrence, Local
  • Male
  • Lymphangioma
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sidle, D. M., Maddalozzo, J., Meier, J. D., Cornwell, M., Stellmach, V., & Crawford, S. E. (2005). Altered pigment epithelium-derived factor and vascular endothelial growth factor levels in lymphangioma pathogenesis and clinical recurrence. Arch Otolaryngol Head Neck Surg, 131(11), 990–995. https://doi.org/10.1001/archotol.131.11.990
Sidle, Douglas M., John Maddalozzo, Jason D. Meier, Mona Cornwell, Veronica Stellmach, and Susan E. Crawford. “Altered pigment epithelium-derived factor and vascular endothelial growth factor levels in lymphangioma pathogenesis and clinical recurrence.Arch Otolaryngol Head Neck Surg 131, no. 11 (November 2005): 990–95. https://doi.org/10.1001/archotol.131.11.990.
Sidle DM, Maddalozzo J, Meier JD, Cornwell M, Stellmach V, Crawford SE. Altered pigment epithelium-derived factor and vascular endothelial growth factor levels in lymphangioma pathogenesis and clinical recurrence. Arch Otolaryngol Head Neck Surg. 2005 Nov;131(11):990–5.
Sidle, Douglas M., et al. “Altered pigment epithelium-derived factor and vascular endothelial growth factor levels in lymphangioma pathogenesis and clinical recurrence.Arch Otolaryngol Head Neck Surg, vol. 131, no. 11, Nov. 2005, pp. 990–95. Pubmed, doi:10.1001/archotol.131.11.990.
Sidle DM, Maddalozzo J, Meier JD, Cornwell M, Stellmach V, Crawford SE. Altered pigment epithelium-derived factor and vascular endothelial growth factor levels in lymphangioma pathogenesis and clinical recurrence. Arch Otolaryngol Head Neck Surg. 2005 Nov;131(11):990–995.

Published In

Arch Otolaryngol Head Neck Surg

DOI

ISSN

0886-4470

Publication Date

November 2005

Volume

131

Issue

11

Start / End Page

990 / 995

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Statistics as Topic
  • Serpins
  • Retrospective Studies
  • Protease Inhibitors
  • Otorhinolaryngology
  • Nerve Growth Factors
  • Neoplasm Recurrence, Local
  • Male
  • Lymphangioma