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Coactivator PRIP, the peroxisome proliferator-activated receptor-interacting protein, is a modulator of placental, cardiac, hepatic, and embryonic development.

Publication ,  Journal Article
Zhu, Y-J; Crawford, SE; Stellmach, V; Dwivedi, RS; Rao, MS; Gonzalez, FJ; Qi, C; Reddy, JK
Published in: J Biol Chem
January 17, 2003

Nuclear receptor coactivator PRIP (peroxisome proliferator-activated receptor (PPAR gamma)-interacting protein) and PRIP-interacting protein with methyltransferase activity, designated PIMT, appear to serve as linkers between cAMP response element-binding protein-binding protein (CBP)/p300-anchored and PBP (PPAR gamma-binding protein)-anchored coactivator complexes involved in the transcriptional activity of nuclear receptors. To assess the biological significance of PRIP, we disrupted the PRIP gene in mice by homologous recombination. Mice nullizygous for PRIP died between embryonic day 11.5 and 12.5 (postcoitum) due in most part to defects in the development of placenta, heart, liver, nervous system, and retardation of embryonic growth. Transient transfection assays using fibroblasts isolated from PRIP(-/-) embryos revealed a significant decrease in the capacity for ligand-dependent transcriptional activation of retinoid X receptor alpha and to a lesser effect on PPAR gamma transcriptional activity. These observations indicate that PRIP like PBP, CBP, and p300 is an essential and nonredundant coactivator.

Duke Scholars

Published In

J Biol Chem

DOI

ISSN

0021-9258

Publication Date

January 17, 2003

Volume

278

Issue

3

Start / End Page

1986 / 1990

Location

United States

Related Subject Headings

  • Transcriptional Activation
  • Transcription Factors
  • Placenta
  • Mice, Knockout
  • Mice
  • Mediator Complex Subunit 1
  • Liver
  • Heart
  • Fetal Growth Retardation
  • Fetal Death
 

Citation

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Zhu, Y.-J., Crawford, S. E., Stellmach, V., Dwivedi, R. S., Rao, M. S., Gonzalez, F. J., … Reddy, J. K. (2003). Coactivator PRIP, the peroxisome proliferator-activated receptor-interacting protein, is a modulator of placental, cardiac, hepatic, and embryonic development. J Biol Chem, 278(3), 1986–1990. https://doi.org/10.1074/jbc.C200634200
Zhu, Yi-Jun, Susan E. Crawford, Veronica Stellmach, Rama S. Dwivedi, M Sambasiva Rao, Frank J. Gonzalez, Chao Qi, and Janardan K. Reddy. “Coactivator PRIP, the peroxisome proliferator-activated receptor-interacting protein, is a modulator of placental, cardiac, hepatic, and embryonic development.J Biol Chem 278, no. 3 (January 17, 2003): 1986–90. https://doi.org/10.1074/jbc.C200634200.
Zhu Y-J, Crawford SE, Stellmach V, Dwivedi RS, Rao MS, Gonzalez FJ, et al. Coactivator PRIP, the peroxisome proliferator-activated receptor-interacting protein, is a modulator of placental, cardiac, hepatic, and embryonic development. J Biol Chem. 2003 Jan 17;278(3):1986–90.
Zhu, Yi-Jun, et al. “Coactivator PRIP, the peroxisome proliferator-activated receptor-interacting protein, is a modulator of placental, cardiac, hepatic, and embryonic development.J Biol Chem, vol. 278, no. 3, Jan. 2003, pp. 1986–90. Pubmed, doi:10.1074/jbc.C200634200.
Zhu Y-J, Crawford SE, Stellmach V, Dwivedi RS, Rao MS, Gonzalez FJ, Qi C, Reddy JK. Coactivator PRIP, the peroxisome proliferator-activated receptor-interacting protein, is a modulator of placental, cardiac, hepatic, and embryonic development. J Biol Chem. 2003 Jan 17;278(3):1986–1990.

Published In

J Biol Chem

DOI

ISSN

0021-9258

Publication Date

January 17, 2003

Volume

278

Issue

3

Start / End Page

1986 / 1990

Location

United States

Related Subject Headings

  • Transcriptional Activation
  • Transcription Factors
  • Placenta
  • Mice, Knockout
  • Mice
  • Mediator Complex Subunit 1
  • Liver
  • Heart
  • Fetal Growth Retardation
  • Fetal Death