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Pigment epithelium-derived factor (PEDF) in neuroblastoma: a multifunctional mediator of Schwann cell antitumor activity.

Publication ,  Journal Article
Crawford, SE; Stellmach, V; Ranalli, M; Huang, X; Huang, L; Volpert, O; De Vries, GH; Abramson, LP; Bouck, N
Published in: J Cell Sci
December 2001

Neuroblastoma is notable for its cellular heterogeneity and unpredictable outcome. Tumors are a variable mixture of primitive malignant neuroblasts, more differentiated ganglionic cells, Schwann and endothelial cells. Although often fatal, neuroblastomas can spontaneously regress, possibly due to favorable autocrine and paracrine interactions among these cells. Here, pigment epithelium-derived factor (PEDF), a potent inhibitor of angiogenesis and inducer of neural differentiation, is shown to be produced by ganglionic cells and Schwann cells, but not by more primitive tumor cells. Although undifferentiated neuroblastoma tumor cell secretions were angiogenic primarily due to vascular endothelial growth factor, secretions of Schwann cells were anti-angiogenic due to PEDF. In addition, PEDF was the major factor responsible for Schwann cell's ability to induce tumor cell differentiation in vitro and recombinant PEDF had the same effect in vitro and in vivo. Both the growth and the survival of Schwann cells were enhanced by PEDF. Thus PEDF may serve as a multifunctional antitumor agent in neuroblastomas, inhibiting angiogenesis while promoting the numbers of Schwann cells and differentiated tumor cells that in turn produce PEDF, suggesting that its clinical administration could stimulate a multifaceted antitumor feedback loop with the potential to limit and possibly regress tumor growth.

Duke Scholars

Published In

J Cell Sci

DOI

ISSN

0021-9533

Publication Date

December 2001

Volume

114

Issue

Pt 24

Start / End Page

4421 / 4428

Location

England

Related Subject Headings

  • Vascular Endothelial Growth Factors
  • Vascular Endothelial Growth Factor A
  • Serpins
  • Schwann Cells
  • Recombinant Proteins
  • Rats, Inbred F344
  • Rats
  • Proteins
  • Pigment Epithelium of Eye
  • Neuroblastoma
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Crawford, S. E., Stellmach, V., Ranalli, M., Huang, X., Huang, L., Volpert, O., … Bouck, N. (2001). Pigment epithelium-derived factor (PEDF) in neuroblastoma: a multifunctional mediator of Schwann cell antitumor activity. J Cell Sci, 114(Pt 24), 4421–4428. https://doi.org/10.1242/jcs.114.24.4421
Crawford, S. E., V. Stellmach, M. Ranalli, X. Huang, L. Huang, O. Volpert, G. H. De Vries, L. P. Abramson, and N. Bouck. “Pigment epithelium-derived factor (PEDF) in neuroblastoma: a multifunctional mediator of Schwann cell antitumor activity.J Cell Sci 114, no. Pt 24 (December 2001): 4421–28. https://doi.org/10.1242/jcs.114.24.4421.
Crawford SE, Stellmach V, Ranalli M, Huang X, Huang L, Volpert O, et al. Pigment epithelium-derived factor (PEDF) in neuroblastoma: a multifunctional mediator of Schwann cell antitumor activity. J Cell Sci. 2001 Dec;114(Pt 24):4421–8.
Crawford, S. E., et al. “Pigment epithelium-derived factor (PEDF) in neuroblastoma: a multifunctional mediator of Schwann cell antitumor activity.J Cell Sci, vol. 114, no. Pt 24, Dec. 2001, pp. 4421–28. Pubmed, doi:10.1242/jcs.114.24.4421.
Crawford SE, Stellmach V, Ranalli M, Huang X, Huang L, Volpert O, De Vries GH, Abramson LP, Bouck N. Pigment epithelium-derived factor (PEDF) in neuroblastoma: a multifunctional mediator of Schwann cell antitumor activity. J Cell Sci. 2001 Dec;114(Pt 24):4421–4428.
Journal cover image

Published In

J Cell Sci

DOI

ISSN

0021-9533

Publication Date

December 2001

Volume

114

Issue

Pt 24

Start / End Page

4421 / 4428

Location

England

Related Subject Headings

  • Vascular Endothelial Growth Factors
  • Vascular Endothelial Growth Factor A
  • Serpins
  • Schwann Cells
  • Recombinant Proteins
  • Rats, Inbred F344
  • Rats
  • Proteins
  • Pigment Epithelium of Eye
  • Neuroblastoma