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A new rat infection-heart transplant model: effect of infection on graft survival studies.

Publication ,  Journal Article
Kobayashi, J; Mavroudis, C; Crawford, SE; Zales, VR; Backer, CL
Published in: J Heart Lung Transplant
1993

Considerable progress has been made in survival rates of heart transplant recipients; however, infections continue to be a major cause of death after transplantation. Although infection itself appears to cause immunologic suppression in some nontransplantation studies, the lack of an infection-transplant animal model has limited further investigation of this observation. We evaluated the utility of a heterotopic rat infection heart-transplant model by studying the effect of infection and limited administration of two immunosuppressive agents, cyclosporine and FK506, on allograft rejection and survival. Lewis rats received ACI heart allografts, and intraperitoneal infection was induced by cecal ligation. Infection was confirmed by blood and ascitic fluid cultures. Results showed that graft survival was slightly, but significantly, higher (p < 0.05) in group II (transplantation with infection) when compared to the control group I (transplantation only). Histologic rejection scores were less (p < 0.05) in group II 6 days after transplantation. The second phase of the study compared the effect of infection after transplantation in rats given a 1-week course of cyclosporine or FK506, which were discontinued after the induction of infection. Although the cyclosporine group had prolonged survival when compared to the FK506 group (p < 0.05), the respective infection groups receiving immunosuppression revealed no significant difference in allograft survival or histologic rejection scores when compared to the control groups. In this preliminary study, infection without immunosuppression resulted in a slight, but statistically significant, increase in allograft survival and reduced acute cellular rejection. In those groups receiving immunosuppressive agents, no additive immunosuppressive effect was attributable to bacterial infection.(ABSTRACT TRUNCATED AT 250 WORDS)

Duke Scholars

Published In

J Heart Lung Transplant

ISSN

1053-2498

Publication Date

1993

Volume

12

Issue

4

Start / End Page

659 / 664

Location

United States

Related Subject Headings

  • Transplantation, Heterotopic
  • Time Factors
  • Tacrolimus
  • Surgery
  • Rats, Inbred Lew
  • Rats, Inbred ACI
  • Rats
  • Male
  • Immunosuppression Therapy
  • Heart Transplantation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kobayashi, J., Mavroudis, C., Crawford, S. E., Zales, V. R., & Backer, C. L. (1993). A new rat infection-heart transplant model: effect of infection on graft survival studies. J Heart Lung Transplant, 12(4), 659–664.
Kobayashi, J., C. Mavroudis, S. E. Crawford, V. R. Zales, and C. L. Backer. “A new rat infection-heart transplant model: effect of infection on graft survival studies.J Heart Lung Transplant 12, no. 4 (1993): 659–64.
Kobayashi J, Mavroudis C, Crawford SE, Zales VR, Backer CL. A new rat infection-heart transplant model: effect of infection on graft survival studies. J Heart Lung Transplant. 1993;12(4):659–64.
Kobayashi, J., et al. “A new rat infection-heart transplant model: effect of infection on graft survival studies.J Heart Lung Transplant, vol. 12, no. 4, 1993, pp. 659–64.
Kobayashi J, Mavroudis C, Crawford SE, Zales VR, Backer CL. A new rat infection-heart transplant model: effect of infection on graft survival studies. J Heart Lung Transplant. 1993;12(4):659–664.
Journal cover image

Published In

J Heart Lung Transplant

ISSN

1053-2498

Publication Date

1993

Volume

12

Issue

4

Start / End Page

659 / 664

Location

United States

Related Subject Headings

  • Transplantation, Heterotopic
  • Time Factors
  • Tacrolimus
  • Surgery
  • Rats, Inbred Lew
  • Rats, Inbred ACI
  • Rats
  • Male
  • Immunosuppression Therapy
  • Heart Transplantation