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Microglia and Perivascular Macrophages Act as Antigen Presenting Cells to Promote CD8 T Cell Infiltration of the Brain.

Publication ,  Journal Article
Goddery, EN; Fain, CE; Lipovsky, CG; Ayasoufi, K; Yokanovich, LT; Malo, CS; Khadka, RH; Tritz, ZP; Jin, F; Hansen, MJ; Johnson, AJ
Published in: Front Immunol
2021

CD8 T cell infiltration of the central nervous system (CNS) is necessary for host protection but contributes to neuropathology. Antigen presenting cells (APCs) situated at CNS borders are thought to mediate T cell entry into the parenchyma during neuroinflammation. The identity of the CNS-resident APC that presents antigen via major histocompatibility complex (MHC) class I to CD8 T cells is unknown. Herein, we characterize MHC class I expression in the naïve and virally infected brain and identify microglia and macrophages (CNS-myeloid cells) as APCs that upregulate H-2Kb and H-2Db upon infection. Conditional ablation of H-2Kb and H-2Db from CNS-myeloid cells allowed us to determine that antigen presentation via H-2Db, but not H-2Kb, was required for CNS immune infiltration during Theiler's murine encephalomyelitis virus (TMEV) infection and drives brain atrophy as a consequence of infection. These results demonstrate that CNS-myeloid cells are key APCs mediating CD8 T cell brain infiltration.

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Published In

Front Immunol

DOI

EISSN

1664-3224

Publication Date

2021

Volume

12

Start / End Page

726421

Location

Switzerland

Related Subject Headings

  • Theilovirus
  • Microglia
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Magnetic Resonance Imaging
  • Macrophages
  • H-2 Antigens
  • Female
  • CD8-Positive T-Lymphocytes
 

Citation

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Chicago
ICMJE
MLA
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Goddery, E. N., Fain, C. E., Lipovsky, C. G., Ayasoufi, K., Yokanovich, L. T., Malo, C. S., … Johnson, A. J. (2021). Microglia and Perivascular Macrophages Act as Antigen Presenting Cells to Promote CD8 T Cell Infiltration of the Brain. Front Immunol, 12, 726421. https://doi.org/10.3389/fimmu.2021.726421
Goddery, Emma N., Cori E. Fain, Chloe G. Lipovsky, Katayoun Ayasoufi, Lila T. Yokanovich, Courtney S. Malo, Roman H. Khadka, et al. “Microglia and Perivascular Macrophages Act as Antigen Presenting Cells to Promote CD8 T Cell Infiltration of the Brain.Front Immunol 12 (2021): 726421. https://doi.org/10.3389/fimmu.2021.726421.
Goddery EN, Fain CE, Lipovsky CG, Ayasoufi K, Yokanovich LT, Malo CS, et al. Microglia and Perivascular Macrophages Act as Antigen Presenting Cells to Promote CD8 T Cell Infiltration of the Brain. Front Immunol. 2021;12:726421.
Goddery, Emma N., et al. “Microglia and Perivascular Macrophages Act as Antigen Presenting Cells to Promote CD8 T Cell Infiltration of the Brain.Front Immunol, vol. 12, 2021, p. 726421. Pubmed, doi:10.3389/fimmu.2021.726421.
Goddery EN, Fain CE, Lipovsky CG, Ayasoufi K, Yokanovich LT, Malo CS, Khadka RH, Tritz ZP, Jin F, Hansen MJ, Johnson AJ. Microglia and Perivascular Macrophages Act as Antigen Presenting Cells to Promote CD8 T Cell Infiltration of the Brain. Front Immunol. 2021;12:726421.

Published In

Front Immunol

DOI

EISSN

1664-3224

Publication Date

2021

Volume

12

Start / End Page

726421

Location

Switzerland

Related Subject Headings

  • Theilovirus
  • Microglia
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Magnetic Resonance Imaging
  • Macrophages
  • H-2 Antigens
  • Female
  • CD8-Positive T-Lymphocytes