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Surveillance imaging in mantle cell lymphoma in first remission lacks clinical utility.

Publication ,  Journal Article
Guidot, DM; Switchenko, JM; Nastoupil, LJ; Koff, JL; Blum, KA; Maly, J; Flowers, CR; Cohen, JB
Published in: Leuk Lymphoma
April 2018

Mantle cell lymphoma (MCL) is a heterogeneous disease with high relapse rates. Limited data guide the use of surveillance imaging following treatment. We constructed a retrospective cohort from two academic institutions of patients with MCL who completed first-line therapy and underwent follow-up for relapse, analyzing the effect of surveillance imaging on survival. Of 217 patients, 102 had documented relapse, with 38 (37%) diagnosed by surveillance imaging and 64 (63%) by other methods. Relapse diagnosis by surveillance imaging had no significant advantage in overall survival from diagnosis date (hazard ratio [HR] = 0.80, p = .39) or relapse date (HR = 0.72, p = .22). Of 801 surveillance images, PET/CT had a positive predictive value (PPV) of 24% and number needed-to-scan/treat (NNT) of 51 to detect one relapse, and CT had a PPV of 49% and NNT of 24. For MCL after first-line therapy, relapse detection by surveillance imaging was not associated with improved survival and lacks clinical benefit.

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Published In

Leuk Lymphoma

DOI

EISSN

1029-2403

Publication Date

April 2018

Volume

59

Issue

4

Start / End Page

888 / 895

Location

United States

Related Subject Headings

  • Survival Analysis
  • Retrospective Studies
  • Proportional Hazards Models
  • Predictive Value of Tests
  • Positron Emission Tomography Computed Tomography
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
  • Lymphoma, Mantle-Cell
  • Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Guidot, D. M., Switchenko, J. M., Nastoupil, L. J., Koff, J. L., Blum, K. A., Maly, J., … Cohen, J. B. (2018). Surveillance imaging in mantle cell lymphoma in first remission lacks clinical utility. Leuk Lymphoma, 59(4), 888–895. https://doi.org/10.1080/10428194.2017.1361032
Guidot, Daniel M., Jeffrey M. Switchenko, Loretta J. Nastoupil, Jean L. Koff, Kristie A. Blum, Joseph Maly, Christopher R. Flowers, and Jonathon B. Cohen. “Surveillance imaging in mantle cell lymphoma in first remission lacks clinical utility.Leuk Lymphoma 59, no. 4 (April 2018): 888–95. https://doi.org/10.1080/10428194.2017.1361032.
Guidot DM, Switchenko JM, Nastoupil LJ, Koff JL, Blum KA, Maly J, et al. Surveillance imaging in mantle cell lymphoma in first remission lacks clinical utility. Leuk Lymphoma. 2018 Apr;59(4):888–95.
Guidot, Daniel M., et al. “Surveillance imaging in mantle cell lymphoma in first remission lacks clinical utility.Leuk Lymphoma, vol. 59, no. 4, Apr. 2018, pp. 888–95. Pubmed, doi:10.1080/10428194.2017.1361032.
Guidot DM, Switchenko JM, Nastoupil LJ, Koff JL, Blum KA, Maly J, Flowers CR, Cohen JB. Surveillance imaging in mantle cell lymphoma in first remission lacks clinical utility. Leuk Lymphoma. 2018 Apr;59(4):888–895.

Published In

Leuk Lymphoma

DOI

EISSN

1029-2403

Publication Date

April 2018

Volume

59

Issue

4

Start / End Page

888 / 895

Location

United States

Related Subject Headings

  • Survival Analysis
  • Retrospective Studies
  • Proportional Hazards Models
  • Predictive Value of Tests
  • Positron Emission Tomography Computed Tomography
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
  • Lymphoma, Mantle-Cell
  • Immunology