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Body mass index and clinical outcomes in individuals with major depressive disorder: Findings from the GSRD European Multicenter Database.

Publication ,  Journal Article
Kraus, C; Kautzky, A; Watzal, V; Gramser, A; Kadriu, B; Deng, Z-D; Bartova, L; Zarate, CA; Lanzenberger, R; Souery, D; Montgomery, S; Zohar, J ...
Published in: Journal of affective disorders
August 2023

Individuals with major depressive disorder (MDD) are at higher risk for obesity. In turn, weight gain is a predisposing factor for depression. Although clinical data are sparse, suicide risk also appears to be elevated in obese patients. This study used data from the European Group for the Study of Resistant Depression (GSRD) to investigate clinical outcomes associated with body mass index (BMI) in MDD.Data were drawn from 892 participants with MDD over the age of 18 years (580 female, 50.5 ± 13.6 years). Response and resistance to antidepressant medication, depression rating scale scores, and further clinical and sociodemographic variables were compared using multiple logistic and linear regressions controlled for age, sex, and risk of weight gain due to psychopharmacotherapy.Of the 892 participants, 323 were categorized as treatment-responsive and 569 as treatment-resistant. Within this cohort, 278 (31.1 %) were overweight (BMI = 25-29.9 kg/m2) and 151 (16.9 %) were obese (BMI > 30 kg/m2). Elevated BMI was significantly associated with higher suicidality, longer duration of psychiatric hospitalizations over their lifetimes, earlier age of onset of MDD, and comorbidities. There was a trend-wise association of BMI with treatment resistance.Data were analyzed in a retrospective, cross-sectional design. BMI was used as an exclusive measure of overweight and obesity.Participants with comorbid MDD and overweight/obesity were at risk for worse clinical outcomes, suggesting that weight gain should be closely monitored in individuals with MDD in daily clinical practice. Further studies are needed to explore the neurobiological mechanisms linking elevated BMI to impaired brain health.

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Published In

Journal of affective disorders

DOI

EISSN

1573-2517

ISSN

0165-0327

Publication Date

August 2023

Volume

335

Start / End Page

349 / 357

Related Subject Headings

  • Weight Gain
  • Retrospective Studies
  • Psychiatry
  • Overweight
  • Obesity
  • Middle Aged
  • Humans
  • Female
  • Depressive Disorder, Major
  • Cross-Sectional Studies
 

Citation

APA
Chicago
ICMJE
MLA
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Kraus, C., Kautzky, A., Watzal, V., Gramser, A., Kadriu, B., Deng, Z.-D., … Kasper, S. (2023). Body mass index and clinical outcomes in individuals with major depressive disorder: Findings from the GSRD European Multicenter Database. Journal of Affective Disorders, 335, 349–357. https://doi.org/10.1016/j.jad.2023.05.042
Kraus, Christoph, Alexander Kautzky, Victoria Watzal, Anna Gramser, Bashkim Kadriu, Zhi-De Deng, Lucie Bartova, et al. “Body mass index and clinical outcomes in individuals with major depressive disorder: Findings from the GSRD European Multicenter Database.Journal of Affective Disorders 335 (August 2023): 349–57. https://doi.org/10.1016/j.jad.2023.05.042.
Kraus C, Kautzky A, Watzal V, Gramser A, Kadriu B, Deng Z-D, et al. Body mass index and clinical outcomes in individuals with major depressive disorder: Findings from the GSRD European Multicenter Database. Journal of affective disorders. 2023 Aug;335:349–57.
Kraus, Christoph, et al. “Body mass index and clinical outcomes in individuals with major depressive disorder: Findings from the GSRD European Multicenter Database.Journal of Affective Disorders, vol. 335, Aug. 2023, pp. 349–57. Epmc, doi:10.1016/j.jad.2023.05.042.
Kraus C, Kautzky A, Watzal V, Gramser A, Kadriu B, Deng Z-D, Bartova L, Zarate CA, Lanzenberger R, Souery D, Montgomery S, Mendlewicz J, Zohar J, Fanelli G, Serretti A, Kasper S. Body mass index and clinical outcomes in individuals with major depressive disorder: Findings from the GSRD European Multicenter Database. Journal of affective disorders. 2023 Aug;335:349–357.
Journal cover image

Published In

Journal of affective disorders

DOI

EISSN

1573-2517

ISSN

0165-0327

Publication Date

August 2023

Volume

335

Start / End Page

349 / 357

Related Subject Headings

  • Weight Gain
  • Retrospective Studies
  • Psychiatry
  • Overweight
  • Obesity
  • Middle Aged
  • Humans
  • Female
  • Depressive Disorder, Major
  • Cross-Sectional Studies