Characterization of implantable biosensor membrane biofouling.

Journal Article (Review;Journal Article)

The material-tissue interaction that results from sensor implantation is one of the major obstacles in developing viable, long-term implantable biosensors. Strategies useful for the characterization and modification of sensor biocompatibility are widely scattered in the literature, and there are many peripheral studies from which useful information can be gleaned. The current paper reviews strategies suitable for addressing biofouling, one aspect of biosensor biocompatibility. Specifically, this paper addresses the effect of membrane biofouling on sensor sensitivity from the standpoint of glucose transport limitations. Part I discusses the in vivo and in vitro methods used to characterize biofouling and the effects of biofouling on sensor performance, while Part II presents techniques intended to improve biosensor biocompatibility.

Full Text

Duke Authors

Cited Authors

  • Wisniewski, N; Moussy, F; Reichert, WM

Published Date

  • March 2000

Published In

Volume / Issue

  • 366 / 6-7

Start / End Page

  • 611 - 621

PubMed ID

  • 11225773

Electronic International Standard Serial Number (EISSN)

  • 1432-1130

International Standard Serial Number (ISSN)

  • 0937-0633

Digital Object Identifier (DOI)

  • 10.1007/s002160051556


  • eng