Drug resistance in Cryptococcus neoformans.


Journal Article

Cryptococcus neoformans has become a major opportunistic fungal pathogen worldwide. Successful treatment of invasive disease with this fungus has used amphotericin B, flucytosine and various azoles. However, treatment failures continue to occur for a variety of reasons including direct antifungal drug resistance. Issues and mechanisms for antifungal drug resistance in Cryptococcus neoformans are reviewed. Furthermore, approaches and strategies for prevention and treatment of antifungal drug resistance are identified and these include host immune modulation, dose optimization, prophylaxis/empirical regimens, improved drug delivery systems such as lipid preparations of amphotericin B, surgery, combination antifungal treatments and development of new antifungal agents. Copyright 1999 Harcourt Publishers Ltd.

Full Text

Duke Authors

Cited Authors

  • Perfect, JR; Cox, GM

Published Date

  • August 1999

Published In

Volume / Issue

  • 2 / 4

Start / End Page

  • 259 - 269

PubMed ID

  • 11504497

Pubmed Central ID

  • 11504497

Electronic International Standard Serial Number (EISSN)

  • 1532-2084

Digital Object Identifier (DOI)

  • 10.1054/drup.1999.0090


  • eng

Conference Location

  • Scotland