Fungal phospholipase activity and susceptibility to lipid preparations of amphotericin B.

Journal Article (Journal Article)

It has been postulated that phospholipases of fungal origin can affect in vitro susceptibility testing of amphotericin B lipid complex (ABLC). We used specific phospholipase-deficient mutants of Candida albicans and Cryptococcus neoformans in susceptibility testing and demonstrated that extracellular fungal phospholipase activity does not influence the in vitro susceptibilities of these two fungi to ABLC.

Full Text

Duke Authors

Cited Authors

  • Gottfredsson, M; Jessup, CJ; Cox, GM; Perfect, JR; Ghannoum, MA

Published Date

  • November 2001

Published In

Volume / Issue

  • 45 / 11

Start / End Page

  • 3231 - 3233

PubMed ID

  • 11600388

Pubmed Central ID

  • PMC90814

International Standard Serial Number (ISSN)

  • 0066-4804

Digital Object Identifier (DOI)

  • 10.1128/AAC.45.11.3231-3233.2001


  • eng

Conference Location

  • United States