Association of plasma levels of human immunodeficiency virus type 1 RNA and oropharyngeal Candida colonization.

Journal Article

The pathophysiology of oropharyngeal candidiasis in patients infected with human immunodeficiency virus (HIV) type 1 is poorly understood. Association between oropharyngeal yeast carriage and various clinical factors in HIV-1-infected patients was studied in 83 patients with no clinical evidence of thrush and no recent antifungal use. Of the clinical factors measured, the only correlate of yeast colonization was with plasma HIV-1 RNA levels (P=.001), whereas the correlation with CD4 cell count was poor (P=.36). By multivariable regression modeling, plasma HIV-1 RNA was the only parameter that correlated with the extent of colonization with Candida infection (P=.003). These data indicate that the presence and amount of asymptomatic oropharyngeal yeast carriage in persons with HIV-1 infection is more significantly correlated with plasma HIV-1 RNA levels than with CD4 cell count. Further studies on the effect of HIV-1 on oropharyngeal yeast colonization, infection, and local immunity are warranted.

Full Text

Duke Authors

Cited Authors

  • Gottfredsson, M; Cox, GM; Indridason, OS; de Almeida, GM; Heald, AE; Perfect, JR

Published Date

  • August 1999

Published In

Volume / Issue

  • 180 / 2

Start / End Page

  • 534 - 537

PubMed ID

  • 10395877

International Standard Serial Number (ISSN)

  • 0022-1899

Digital Object Identifier (DOI)

  • 10.1086/314887

Language

  • eng

Conference Location

  • United States