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Neutralizing and infection-enhancing antibody responses to human immunodeficiency virus type 1 in long-term nonprogressors.

Publication ,  Journal Article
Montefiori, DC; Pantaleo, G; Fink, LM; Zhou, JT; Zhou, JY; Bilska, M; Miralles, GD; Fauci, AS
Published in: J Infect Dis
January 1996

Serum antibodies from human immunodeficiency virus type 1 (HIV-1)-infected long-term non-progressors (LTNPs) and non-LTNPs were evaluated for virus neutralization and infection enhancement in vitro. Sera from LTNPs had higher average titers of neutralizing antibodies to HIV-1 strains IIIB and MN and more frequently neutralized primary isolates from progressors (14.9% vs. 1.3%, P = .002). Replication-competent HIV-1 was isolated from peripheral blood mononuclear cells and lymph nodes of 3 LTNPs. All viruses from LTNPs had a non-syncytium-inducing phenotype, were resistant to neutralization by autologous serum obtained at the time of virus isolation, and showed little evidence of a heightened sensitivity to neutralization by heterologous sera. Complement-mediated, antibody-dependent enhancement (C'-ADE) of HIV-1IIIB and primary isolates was equally prevalent for sera from LTNPs and non-LTNPs. Results indicate that LTNPs produce vigorous serum antibody responses and that long-term nonprogression is not associated with homologous neutralization or the absence of C'-ADE.

Duke Scholars

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Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

January 1996

Volume

173

Issue

1

Start / End Page

60 / 67

Location

United States

Related Subject Headings

  • Neutralization Tests
  • Middle Aged
  • Microbiology
  • Male
  • Lymph Nodes
  • Leukocytes, Mononuclear
  • Immunophenotyping
  • Humans
  • HIV-1
  • HIV Seropositivity
 

Citation

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MLA
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Montefiori, D. C., Pantaleo, G., Fink, L. M., Zhou, J. T., Zhou, J. Y., Bilska, M., … Fauci, A. S. (1996). Neutralizing and infection-enhancing antibody responses to human immunodeficiency virus type 1 in long-term nonprogressors. J Infect Dis, 173(1), 60–67. https://doi.org/10.1093/infdis/173.1.60
Montefiori, D. C., G. Pantaleo, L. M. Fink, J. T. Zhou, J. Y. Zhou, M. Bilska, G. D. Miralles, and A. S. Fauci. “Neutralizing and infection-enhancing antibody responses to human immunodeficiency virus type 1 in long-term nonprogressors.J Infect Dis 173, no. 1 (January 1996): 60–67. https://doi.org/10.1093/infdis/173.1.60.
Montefiori DC, Pantaleo G, Fink LM, Zhou JT, Zhou JY, Bilska M, et al. Neutralizing and infection-enhancing antibody responses to human immunodeficiency virus type 1 in long-term nonprogressors. J Infect Dis. 1996 Jan;173(1):60–7.
Montefiori, D. C., et al. “Neutralizing and infection-enhancing antibody responses to human immunodeficiency virus type 1 in long-term nonprogressors.J Infect Dis, vol. 173, no. 1, Jan. 1996, pp. 60–67. Pubmed, doi:10.1093/infdis/173.1.60.
Montefiori DC, Pantaleo G, Fink LM, Zhou JT, Zhou JY, Bilska M, Miralles GD, Fauci AS. Neutralizing and infection-enhancing antibody responses to human immunodeficiency virus type 1 in long-term nonprogressors. J Infect Dis. 1996 Jan;173(1):60–67.
Journal cover image

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

January 1996

Volume

173

Issue

1

Start / End Page

60 / 67

Location

United States

Related Subject Headings

  • Neutralization Tests
  • Middle Aged
  • Microbiology
  • Male
  • Lymph Nodes
  • Leukocytes, Mononuclear
  • Immunophenotyping
  • Humans
  • HIV-1
  • HIV Seropositivity