Neutralization escape in human immunodeficiency virus type 1-infected long-term nonprogressors.


Journal Article

Neutralization-escape variants of human immunodeficiency virus type 1 (HIV-1) were sought in persons who had persistent low virus loads and who remained asymptomatic for at least 12-16 years of infection without antiretroviral therapy. Viruses were isolated from 3 persons at two or three time points during the course of infection and were assessed for neutralization by sequential autologous serum samples. Virus neutralization was poor or undetectable with contemporaneous autologous serum but improved with later serum samples for each person. In particular, later isolates resisted neutralization by autologous serum samples that neutralized an earlier isolate. Strain-specific neutralizing antibodies remained detectable for up to 4.2 years without diminishing in titer. The results demonstrate that neutralization-escape variants arise periodically in HIV-1-infected long-term nonprogressors.

Full Text

Duke Authors

Cited Authors

  • Bradney, AP; Scheer, S; Crawford, JM; Buchbinder, SP; Montefiori, DC

Published Date

  • May 1999

Published In

Volume / Issue

  • 179 / 5

Start / End Page

  • 1264 - 1267

PubMed ID

  • 10191234

Pubmed Central ID

  • 10191234

International Standard Serial Number (ISSN)

  • 0022-1899

Digital Object Identifier (DOI)

  • 10.1086/314711


  • eng

Conference Location

  • United States