Neutralization escape in human immunodeficiency virus type 1-infected long-term nonprogressors.
Neutralization-escape variants of human immunodeficiency virus type 1 (HIV-1) were sought in persons who had persistent low virus loads and who remained asymptomatic for at least 12-16 years of infection without antiretroviral therapy. Viruses were isolated from 3 persons at two or three time points during the course of infection and were assessed for neutralization by sequential autologous serum samples. Virus neutralization was poor or undetectable with contemporaneous autologous serum but improved with later serum samples for each person. In particular, later isolates resisted neutralization by autologous serum samples that neutralized an earlier isolate. Strain-specific neutralizing antibodies remained detectable for up to 4.2 years without diminishing in titer. The results demonstrate that neutralization-escape variants arise periodically in HIV-1-infected long-term nonprogressors.
Duke Scholars
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- Viral Load
- Neutralization Tests
- Microbiology
- Humans
- HIV-1
- HIV Long-Term Survivors
- HIV Infections
- HIV Antibodies
- 42 Health sciences
- 32 Biomedical and clinical sciences
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Viral Load
- Neutralization Tests
- Microbiology
- Humans
- HIV-1
- HIV Long-Term Survivors
- HIV Infections
- HIV Antibodies
- 42 Health sciences
- 32 Biomedical and clinical sciences