Tryptophan depletion in recently manic patients treated with lithium.


Journal Article

BACKGROUND: Serotonin has been repeatedly implicated in the mechanism of action of lithium against acute mania. Its role, however, has never been directly confirmed. METHODS: We studied recently manic patients successfully treated with lithium using a tryptophan depletion methodology. RESULTS: Patients remained euthymic despite a confirmed decrease in serum tryptophan levels. CONCLUSIONS: These data do not suggest that serotonin plays a critical role in the acute antimanic effect of lithium.

Full Text

Cited Authors

  • Cassidy, F; Murry, E; Carroll, BJ

Published Date

  • February 1998

Published In

Volume / Issue

  • 43 / 3

Start / End Page

  • 230 - 232

PubMed ID

  • 9494705

Pubmed Central ID

  • 9494705

Electronic International Standard Serial Number (EISSN)

  • 1873-2402

International Standard Serial Number (ISSN)

  • 0006-3223

Digital Object Identifier (DOI)

  • 10.1016/s0006-3223(97)00010-3


  • eng