Lack of relapse with tryptophan depletion following successful treatment with ECT.
Publication
, Journal Article
Cassidy, F; Murry, E; Weiner, RD; Carroll, BJ
Published in: Am J Psychiatry
August 1997
OBJECTIVE: Although the antidepressant mechanism of ECT is unknown, there are considerable data to support serotonergic involvement. The effects of tryptophan depletion were studied in patients with major depression treated successfully with ECT. METHOD: Five patients who had been successfully treated with ECT for major depression were studied in a randomized, double-blind, crossover design comparing tryptophan depletion to a placebo procedure. RESULTS: No effect of tryptophan depletion on mood symptoms was observed despite more than an 85% decrease in total serum tryptophan. CONCLUSIONS: These data suggest that presynaptic serotonin availability may not be necessary for the acute maintenance of an antidepressant response to ECT.
Duke Scholars
Published In
Am J Psychiatry
DOI
ISSN
0002-953X
Publication Date
August 1997
Volume
154
Issue
8
Start / End Page
1151 / 1152
Location
United States
Related Subject Headings
- Tryptophan
- Serotonin
- Recurrence
- Psychiatry
- Placebos
- Middle Aged
- Male
- Humans
- Food, Formulated
- Female
Citation
APA
Chicago
ICMJE
MLA
NLM
Cassidy, F., Murry, E., Weiner, R. D., & Carroll, B. J. (1997). Lack of relapse with tryptophan depletion following successful treatment with ECT. Am J Psychiatry, 154(8), 1151–1152. https://doi.org/10.1176/ajp.154.8.1151
Cassidy, F., E. Murry, R. D. Weiner, and B. J. Carroll. “Lack of relapse with tryptophan depletion following successful treatment with ECT.” Am J Psychiatry 154, no. 8 (August 1997): 1151–52. https://doi.org/10.1176/ajp.154.8.1151.
Cassidy F, Murry E, Weiner RD, Carroll BJ. Lack of relapse with tryptophan depletion following successful treatment with ECT. Am J Psychiatry. 1997 Aug;154(8):1151–2.
Cassidy, F., et al. “Lack of relapse with tryptophan depletion following successful treatment with ECT.” Am J Psychiatry, vol. 154, no. 8, Aug. 1997, pp. 1151–52. Pubmed, doi:10.1176/ajp.154.8.1151.
Cassidy F, Murry E, Weiner RD, Carroll BJ. Lack of relapse with tryptophan depletion following successful treatment with ECT. Am J Psychiatry. 1997 Aug;154(8):1151–1152.
Published In
Am J Psychiatry
DOI
ISSN
0002-953X
Publication Date
August 1997
Volume
154
Issue
8
Start / End Page
1151 / 1152
Location
United States
Related Subject Headings
- Tryptophan
- Serotonin
- Recurrence
- Psychiatry
- Placebos
- Middle Aged
- Male
- Humans
- Food, Formulated
- Female