Vascular risk factors in late onset mania.


Journal Article

BACKGROUND: Previous researches have suggested that late onset mania is a distinct subtype associated with medical and neurological disorders. Few studies, however, have focused on vascular risk factors. METHODS: Records of 366 bipolar patients were reviewed and age of first psychiatric hospitalization determined. Late-onset cases were determined empirically from a distribution histogram. Late onset cases were matched to early onset cases and histories of vascular disease/risks and current cholesterol levels compared. RESULTS: The distribution of age of first psychiatric hospitalization was bimodal with an intermode at age 47. Using that threshold, 6.3% of the cohort was classified as having late onset mania. Vascular risks factors were greater and current cholesterol levels higher in the late onset group. CONCLUSIONS: Late onset mania is associated with greater vascular risk factors. The bimodal appearance of age of first psychiatric hospitalization in this study provides further support of late onset mania as a distinct manic subtype with possibly a different, vascular aetiology. Control of these vascular risks may impact on the incidence of late onset mania, as well as on its clinical management.

Full Text

Cited Authors

  • Cassidy, F; Carroll, BJ

Published Date

  • February 2002

Published In

Volume / Issue

  • 32 / 2

Start / End Page

  • 359 - 362

PubMed ID

  • 11866328

Pubmed Central ID

  • 11866328

International Standard Serial Number (ISSN)

  • 0033-2917

Digital Object Identifier (DOI)

  • 10.1017/s0033291701004718


  • eng

Conference Location

  • England