Bone marrow transplantation. Part II--autologous.

Journal Article (Review)

Autologous bone marrow transplantation provides an effective form of "rescue" following high-dose therapy used for treating certain malignant diseases. The high doses of radiotherapy or chemotherapy, or both, should allow for greater tumor cell kill if dose-response to therapy exists for that tumor. The use of autologous bone marrow obviates the need for an HLA-identical donor, and the need for pretransplant immunosuppression; no graft-versus-host disease would ensue. We review in part II the history and background, methods of obtaining autologous stem cells, and details of the results achievable with this type of therapy. We discuss potential difficulties with autologous transplantation, as well as possible future areas of research.

Full Text

Duke Authors

Cited Authors

  • Chao, NJ; Blume, KG

Published Date

  • January 1990

Published In

Volume / Issue

  • 152 / 1

Start / End Page

  • 46 - 51

PubMed ID

  • 2408234

International Standard Serial Number (ISSN)

  • 0093-0415

Language

  • eng

Conference Location

  • United States