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Mobilization of peripheral blood progenitor cells by hematopoietic growth factors.

Publication ,  Journal Article
Chao, NJ
Published in: Can J Oncol
December 1995

The anti-tumor effect and toxicity of chemotherapeutic agents are dose-related. The dose-response curve for these agents is sigmoidal with a threshold, a lag phase, a linear phase and a plateau phase. The aim of cancer chemotherapy is to exploit the difference between the response curves for the tumor and normal tissues. In the laboratory and in some animal models, the dose-response curve for many agents demonstrates a log-linear relationship between dose and cell kill so that a doubling of the drug dose may increase cell kill by ten-fold. The more effective a drug is, the steeper the dose-response curve. Dose may be an important variable in the outcome of therapy, however, this dose-response relationship has been difficult to demonstrate because a dose-response effect may not be evident for most human tumors in the dose ranges used in clinical trials.

Duke Scholars

Published In

Can J Oncol

ISSN

1183-2509

Publication Date

December 1995

Volume

5 Suppl 1

Start / End Page

43 / 46

Location

Canada

Related Subject Headings

  • Tumor Cells, Cultured
  • Treatment Outcome
  • Neoplasms
  • Linear Models
  • Humans
  • Hematopoietic Stem Cells
  • Hematopoietic Cell Growth Factors
  • Dose-Response Relationship, Drug
  • Disease Models, Animal
  • Clinical Trials as Topic
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chao, N. J. “Mobilization of peripheral blood progenitor cells by hematopoietic growth factors.Can J Oncol 5 Suppl 1 (December 1995): 43–46.
Chao, N. J. “Mobilization of peripheral blood progenitor cells by hematopoietic growth factors.Can J Oncol, vol. 5 Suppl 1, Dec. 1995, pp. 43–46.

Published In

Can J Oncol

ISSN

1183-2509

Publication Date

December 1995

Volume

5 Suppl 1

Start / End Page

43 / 46

Location

Canada

Related Subject Headings

  • Tumor Cells, Cultured
  • Treatment Outcome
  • Neoplasms
  • Linear Models
  • Humans
  • Hematopoietic Stem Cells
  • Hematopoietic Cell Growth Factors
  • Dose-Response Relationship, Drug
  • Disease Models, Animal
  • Clinical Trials as Topic