Skip to main content

T helper 2-dominant antilymphoma immune response is associated with fatal outcome.

Publication ,  Journal Article
Lee, PP; Zeng, D; McCaulay, AE; Chen, YF; Geiler, C; Umetsu, DT; Chao, NJ
Published in: Blood
August 15, 1997

The precise role of the endogenous immune system in modulating cancer development remains unclear. Tumor cells are generally thought to be nonimmunogenic because they are of 'self' origin. However, tumor-reactive lymphocytes can be isolated from patients with many types of cancer. It is unclear what role these lymphocytes play and why they fail to protect the host. Using a murine B-cell leukemia/lymphoma (BCL1) model, we showed the development of a vigorous antitumor T-cell response in the tumor-susceptible host. Specific T-cell responses against BCL1 developed as early as day 4. However, the nature of this nonprotective response is different from the protective response produced in a major histocompatibility complex-matched tumor-resistant host. Susceptible hosts developed a T helper 2 (Th2)-dominant response, whereas resistant hosts developed a Th1-dominant response to BCL1. Cytolytic activity against BCL1 developed in both resistant and susceptible hosts, but in the susceptible host, this response was weaker and delayed compared with that in the resistant host. Thus, tumor susceptibility does not necessarily mean the absence of an antitumor immune response. Rather, the nature of the antitumor immune response is critical in determining clinical outcome.

Duke Scholars

Published In

Blood

ISSN

0006-4971

Publication Date

August 15, 1997

Volume

90

Issue

4

Start / End Page

1611 / 1617

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Th2 Cells
  • Th1 Cells
  • Phenotype
  • Neoplasm Transplantation
  • Mice, Inbred BALB C
  • Mice
  • Male
  • Lymphoma, B-Cell
  • Leukemia, B-Cell
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lee, P. P., Zeng, D., McCaulay, A. E., Chen, Y. F., Geiler, C., Umetsu, D. T., & Chao, N. J. (1997). T helper 2-dominant antilymphoma immune response is associated with fatal outcome. Blood, 90(4), 1611–1617.
Lee, P. P., D. Zeng, A. E. McCaulay, Y. F. Chen, C. Geiler, D. T. Umetsu, and N. J. Chao. “T helper 2-dominant antilymphoma immune response is associated with fatal outcome.Blood 90, no. 4 (August 15, 1997): 1611–17.
Lee PP, Zeng D, McCaulay AE, Chen YF, Geiler C, Umetsu DT, et al. T helper 2-dominant antilymphoma immune response is associated with fatal outcome. Blood. 1997 Aug 15;90(4):1611–7.
Lee, P. P., et al. “T helper 2-dominant antilymphoma immune response is associated with fatal outcome.Blood, vol. 90, no. 4, Aug. 1997, pp. 1611–17.
Lee PP, Zeng D, McCaulay AE, Chen YF, Geiler C, Umetsu DT, Chao NJ. T helper 2-dominant antilymphoma immune response is associated with fatal outcome. Blood. 1997 Aug 15;90(4):1611–1617.

Published In

Blood

ISSN

0006-4971

Publication Date

August 15, 1997

Volume

90

Issue

4

Start / End Page

1611 / 1617

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Th2 Cells
  • Th1 Cells
  • Phenotype
  • Neoplasm Transplantation
  • Mice, Inbred BALB C
  • Mice
  • Male
  • Lymphoma, B-Cell
  • Leukemia, B-Cell