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High-dose therapy and autologous bone marrow transplantation for follicular lymphoma in first complete or partial remission: results of a phase II clinical trial.

Publication ,  Journal Article
Horning, SJ; Negrin, RS; Hoppe, RT; Rosenberg, SA; Chao, NJ; Long, GD; Brown, BW; Blume, KG
Published in: Blood
January 15, 2001

Advanced stage follicular small cleaved and mixed cell lymphoma is characterized by relapse from remission and survival ranging from 6 to 12 years. Because young patients have the greatest compromise in longevity, the efficacy and toxicity of high-dose radiochemotherapy and bone marrow transplantation after conventional chemotherapy was evaluated in a prospective phase II clinical trial. Thirty-seven patients in a minimal disease state after conventional chemotherapy received fractionated total body irradiation and high-dose etoposide and cyclophosphamide, followed by purged autologous bone marrow. A reference sample of 188 patients of similar age, stage, and histology managed at this institution before 1988 was identified for comparison of patient characteristics and outcomes. Compared with reference patients, transplant recipients had a higher tumor burden at diagnosis. With a median follow-up of 6.5 years, the estimated 10-year survival after transplantation was 86%. There was a single lymphoma death yielding a 10-year disease-specific survival of 97%. There were 2 early transplant-related deaths and 2 late acute leukemia deaths. Ten patients relapsed, one with microscopic disease only. High tumor burden at diagnosis and incomplete response to chemotherapy adversely influenced survival in the reference but not in the transplanted patients. The estimated risk of death of 14% and relapse of 30% at 10 years in our transplanted follicular lymphoma patients, the majority of whom had high tumor burdens, compares favorably with our observations in appropriately matched reference patients.

Duke Scholars

Published In

Blood

DOI

ISSN

0006-4971

Publication Date

January 15, 2001

Volume

97

Issue

2

Start / End Page

404 / 409

Location

United States

Related Subject Headings

  • Vincristine
  • Transplantation, Autologous
  • Survival Rate
  • Remission Induction
  • Recurrence
  • Radiotherapy, Adjuvant
  • Prospective Studies
  • Prednisone
  • Neoplasm, Residual
  • Middle Aged
 

Citation

APA
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ICMJE
MLA
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Horning, S. J., Negrin, R. S., Hoppe, R. T., Rosenberg, S. A., Chao, N. J., Long, G. D., … Blume, K. G. (2001). High-dose therapy and autologous bone marrow transplantation for follicular lymphoma in first complete or partial remission: results of a phase II clinical trial. Blood, 97(2), 404–409. https://doi.org/10.1182/blood.v97.2.404
Horning, S. J., R. S. Negrin, R. T. Hoppe, S. A. Rosenberg, N. J. Chao, G. D. Long, B. W. Brown, and K. G. Blume. “High-dose therapy and autologous bone marrow transplantation for follicular lymphoma in first complete or partial remission: results of a phase II clinical trial.Blood 97, no. 2 (January 15, 2001): 404–9. https://doi.org/10.1182/blood.v97.2.404.
Horning, S. J., et al. “High-dose therapy and autologous bone marrow transplantation for follicular lymphoma in first complete or partial remission: results of a phase II clinical trial.Blood, vol. 97, no. 2, Jan. 2001, pp. 404–09. Pubmed, doi:10.1182/blood.v97.2.404.
Horning SJ, Negrin RS, Hoppe RT, Rosenberg SA, Chao NJ, Long GD, Brown BW, Blume KG. High-dose therapy and autologous bone marrow transplantation for follicular lymphoma in first complete or partial remission: results of a phase II clinical trial. Blood. 2001 Jan 15;97(2):404–409.

Published In

Blood

DOI

ISSN

0006-4971

Publication Date

January 15, 2001

Volume

97

Issue

2

Start / End Page

404 / 409

Location

United States

Related Subject Headings

  • Vincristine
  • Transplantation, Autologous
  • Survival Rate
  • Remission Induction
  • Recurrence
  • Radiotherapy, Adjuvant
  • Prospective Studies
  • Prednisone
  • Neoplasm, Residual
  • Middle Aged