Pathophysiologic mechanisms of acute graft-vs.-host disease.


Journal Article (Review)

Graft-vs.-host disease (GVHD) remains the major toxicity of allogeneic bone marrow transplantation. Mechanistic studies in experimental animal models provide a better understanding of the complex relationships and cascade of events mediated by cellular and inflammatory factors. Also, advances in basic immunology have cleared the way for a more precise view of allogeneic reactions between donor and host. In addition, the use of mutant mice lacking critical cytolytic proteins has helped map out the molecular pathways by which GVHD targets organ damage. In this article, these mechanisms are reviewed and synthesized into a coherent conceptual framework, providing a state-of-the-art summary of the pathophysiology of acute GVHD.

Full Text

Duke Authors

Cited Authors

  • Ferrara, JL; Levy, R; Chao, NJ

Published Date

  • 1999

Published In

Volume / Issue

  • 5 / 6

Start / End Page

  • 347 - 356

PubMed ID

  • 10595812

Pubmed Central ID

  • 10595812

International Standard Serial Number (ISSN)

  • 1083-8791

Digital Object Identifier (DOI)

  • 10.1016/s1083-8791(99)70011-x


  • eng

Conference Location

  • United States