Importance of bone marrow cytogenetic evaluation before autologous bone marrow transplantation for Hodgkin's disease.


Journal Article

Alkylating agents used either with or without radiation therapy have been associated with the development of myelodysplastic syndrome (MDS) and acute nonlymphoblastic leukemia (ANLL) after treatment of both malignant and nonmalignant disorders. This report describes seven patients with recurrent Hodgkin's disease (HD) evaluated for bone marrow transplantation (BMT) who developed chromosomal abnormalities, and emphasizes the importance of bone marrow cytogenetic studies before bone marrow harvest. Three patients with histologically normal bone marrow underwent autologous BMT and subsequently developed an MDS or ANLL. Four patients had the clonal abnormality detected before bone marrow harvest and did not proceed to BMT.

Full Text

Duke Authors

Cited Authors

  • Chao, NJ; Nademanee, AP; Long, GD; Schmidt, GM; Donlon, TA; Parker, P; Slovak, ML; Nagasawa, LS; Blume, KG; Forman, SJ

Published Date

  • September 1, 1991

Published In

Volume / Issue

  • 9 / 9

Start / End Page

  • 1575 - 1579

PubMed ID

  • 1875219

Pubmed Central ID

  • 1875219

International Standard Serial Number (ISSN)

  • 0732-183X

Digital Object Identifier (DOI)

  • 10.1200/JCO.1991.9.9.1575


  • eng

Conference Location

  • United States