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Secondary myelodysplasia and acute leukemia in breast cancer patients after autologous bone marrow transplant.

Publication ,  Journal Article
Laughlin, MJ; McGaughey, DS; Crews, JR; Chao, NJ; Rizzieri, D; Ross, M; Gockerman, J; Cirrincione, C; Berry, D; Mills, L; Defusco, P ...
Published in: J Clin Oncol
March 1998

PURPOSE: To determine the incidence of myelodysplasia (MDS) and/or acute leukemia (AL) in breast cancer patients after high-dose chemotherapy (HDC) with a single conditioning regimen and autologous bone marrow transplant (ABMT), and analyze the cytogenetic abnormalities that arise after HDC. PATIENTS AND METHODS: We retrospectively reviewed the records of 864 breast cancer patients who underwent ABMT at Duke University Medical Center, Durham, NC, from 1985 through 1996 who received the same preparative regimen of cyclophosphamide 1,875 mg/m2 for 3 days, cisplatin 55 mg/m2 for 3 days, and BCNU 600 mg/m2 for 1 day (CPB). Pretransplant cytogenetics were analyzed in all patients and posttransplant cytogenetics were evaluated in four of five patients who developed MDS/AL. RESULTS: Five of 864 patients developed MDS/AL after HDC with CPB and ABMT. The crude cumulative incidence of MDS/AL was 0.58%. The Kaplan-Meier curve shows a 4-year probability of developing MDS/AL of 1.6%. Pretransplant cytogenetics performed on these five patients were all normal. Posttransplant cytogenetics were performed on four of five patients and they were abnormal in all four, although only one patient had the most common cytogenetic abnormality associated with secondary MDS/AL (chromosome 5 and/or 7 abnormality). CONCLUSION: Whereas MDS/AL is a potential complication of HDC with CPB and ABMT, the incidence in this series of patients with breast cancer was relatively low compared with that reported in patients with non-Hodgkin's lymphoma who underwent ABMT. The cytogenetic abnormalities reported in this group of breast cancer patients were not typical of those seen in prior reports of secondary MDS/AL and appear to have occurred after HDC.

Duke Scholars

Published In

J Clin Oncol

DOI

ISSN

0732-183X

Publication Date

March 1998

Volume

16

Issue

3

Start / End Page

1008 / 1012

Location

United States

Related Subject Headings

  • Transplantation, Autologous
  • Survival Analysis
  • Retrospective Studies
  • Oncology & Carcinogenesis
  • Myelodysplastic Syndromes
  • Leukemia
  • Karyotyping
  • Humans
  • Female
  • Cyclophosphamide
 

Citation

APA
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Laughlin, M. J., McGaughey, D. S., Crews, J. R., Chao, N. J., Rizzieri, D., Ross, M., … Vredenburgh, J. J. (1998). Secondary myelodysplasia and acute leukemia in breast cancer patients after autologous bone marrow transplant. J Clin Oncol, 16(3), 1008–1012. https://doi.org/10.1200/JCO.1998.16.3.1008
Laughlin, M. J., D. S. McGaughey, J. R. Crews, N. J. Chao, D. Rizzieri, M. Ross, J. Gockerman, et al. “Secondary myelodysplasia and acute leukemia in breast cancer patients after autologous bone marrow transplant.J Clin Oncol 16, no. 3 (March 1998): 1008–12. https://doi.org/10.1200/JCO.1998.16.3.1008.
Laughlin MJ, McGaughey DS, Crews JR, Chao NJ, Rizzieri D, Ross M, et al. Secondary myelodysplasia and acute leukemia in breast cancer patients after autologous bone marrow transplant. J Clin Oncol. 1998 Mar;16(3):1008–12.
Laughlin, M. J., et al. “Secondary myelodysplasia and acute leukemia in breast cancer patients after autologous bone marrow transplant.J Clin Oncol, vol. 16, no. 3, Mar. 1998, pp. 1008–12. Pubmed, doi:10.1200/JCO.1998.16.3.1008.
Laughlin MJ, McGaughey DS, Crews JR, Chao NJ, Rizzieri D, Ross M, Gockerman J, Cirrincione C, Berry D, Mills L, Defusco P, LeGrand S, Peters WP, Vredenburgh JJ. Secondary myelodysplasia and acute leukemia in breast cancer patients after autologous bone marrow transplant. J Clin Oncol. 1998 Mar;16(3):1008–1012.

Published In

J Clin Oncol

DOI

ISSN

0732-183X

Publication Date

March 1998

Volume

16

Issue

3

Start / End Page

1008 / 1012

Location

United States

Related Subject Headings

  • Transplantation, Autologous
  • Survival Analysis
  • Retrospective Studies
  • Oncology & Carcinogenesis
  • Myelodysplastic Syndromes
  • Leukemia
  • Karyotyping
  • Humans
  • Female
  • Cyclophosphamide