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A new preparatory regimen for autologous bone marrow transplantation for patients with lymphoma.

Publication ,  Journal Article
Chao, NJ; Kastrissios, H; Long, GD; Negrin, RS; Horning, SJ; Wong, RM; Blaschke, TF; Blume, KG
Published in: Cancer
March 15, 1995

BACKGROUND: This trial studied the feasibility and efficacy of a new preparatory regimen for autologous bone marrow transplantation for patients with advanced lymphoid malignancies. METHODS: Twenty-one patients with Hodgkin's disease (n = 12) and non-Hodgkin's lymphoma (n = 9) were treated in this study. Lomustine was substituted for carmustine) in a dose-escalation study with an initial dose of 6 mg/kg and increasing by 3 mg/kg in groups of four patients. The preparatory regimen consisted of lomustine (6-15 mg/kg) orally on Day -6, etoposide (60 mg/kg) intravenously (i.v.) on Day -4, and cyclophosphamide (100 mg/kg) i.v. on Day -2. Peripheral blood progenitor cells and/or bone marrow were infused on Day 0. RESULTS: Lomustine was well tolerated in all patients with no significant toxicity specific to this drug. Engraftment was prompt: the time to achieving greater than or equal to 500 granulocytes/microliters was 12 days (range, 9-16 days) and the time to achieving greater than or equal to 25,000 platelets/microliters without transfusion support was 16 days (range, 9-22 days). Five patients experienced interstitial pneumonitis, three of whom had active or recent interstitial pneumonitis before bone marrow transplantation, and one who just completed mantle irradiation. Three patients died from this preparatory regimen, one of progressive interstitial pneumonitis, one of Legionella pneumonia, and one of multiorgan failure. Three patients with non-Hodgkin's lymphoma relapsed. Fourteen patients are currently alive and disease free to date. The actuarial are currently alive and disease free to date. The actuarial disease free survival was 57%, with a median follow-up of 23 months (range, 1-48 months). CONCLUSION: The preparatory regimen consisting of lomustine/etoposide/cyclophosphamide is active in treating patients with lymphomas. Further trials with high doses of lomustine are warranted.

Duke Scholars

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

March 15, 1995

Volume

75

Issue

6

Start / End Page

1354 / 1359

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Autologous
  • Oncology & Carcinogenesis
  • Middle Aged
  • Lymphoma
  • Lung Diseases, Interstitial
  • Lomustine
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Etoposide
 

Citation

APA
Chicago
ICMJE
MLA
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Chao, N. J., Kastrissios, H., Long, G. D., Negrin, R. S., Horning, S. J., Wong, R. M., … Blume, K. G. (1995). A new preparatory regimen for autologous bone marrow transplantation for patients with lymphoma. Cancer, 75(6), 1354–1359. https://doi.org/10.1002/1097-0142(19950315)75:6<1354::aid-cncr2820750618>3.0.co;2-m
Chao, N. J., H. Kastrissios, G. D. Long, R. S. Negrin, S. J. Horning, R. M. Wong, T. F. Blaschke, and K. G. Blume. “A new preparatory regimen for autologous bone marrow transplantation for patients with lymphoma.Cancer 75, no. 6 (March 15, 1995): 1354–59. https://doi.org/10.1002/1097-0142(19950315)75:6<1354::aid-cncr2820750618>3.0.co;2-m.
Chao NJ, Kastrissios H, Long GD, Negrin RS, Horning SJ, Wong RM, et al. A new preparatory regimen for autologous bone marrow transplantation for patients with lymphoma. Cancer. 1995 Mar 15;75(6):1354–9.
Chao, N. J., et al. “A new preparatory regimen for autologous bone marrow transplantation for patients with lymphoma.Cancer, vol. 75, no. 6, Mar. 1995, pp. 1354–59. Pubmed, doi:10.1002/1097-0142(19950315)75:6<1354::aid-cncr2820750618>3.0.co;2-m.
Chao NJ, Kastrissios H, Long GD, Negrin RS, Horning SJ, Wong RM, Blaschke TF, Blume KG. A new preparatory regimen for autologous bone marrow transplantation for patients with lymphoma. Cancer. 1995 Mar 15;75(6):1354–1359.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

March 15, 1995

Volume

75

Issue

6

Start / End Page

1354 / 1359

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Autologous
  • Oncology & Carcinogenesis
  • Middle Aged
  • Lymphoma
  • Lung Diseases, Interstitial
  • Lomustine
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Etoposide