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Influence of age on the outcome of 500 autologous bone marrow transplant procedures for hematologic malignancies.

Publication ,  Journal Article
Kusnierz-Glaz, CR; Schlegel, PG; Wong, RM; Schriber, JR; Chao, NJ; Amylon, MD; Hu, WW; Negrin, RS; Lee, Y; Blume, KG; Long, GD
Published in: J Clin Oncol
January 1997

PURPOSE: To determine the effect of age on the outcome of autologous bone marrow transplantation (ABMT) and/or peripheral-blood progenitor-cell (PBPC) transplantation. PATIENTS AND METHODS: A retrospective analysis was performed on 500 consecutive patients who ranged in age from 1 to 65 years (median, 40) with non-Hodgkin's lymphoma (NHL), Hodgkin's disease (HD), multiple myeloma (MM), or acute nonlymphoblastic leukemia (AML) who underwent autologous hematopoietic-cell transplant procedures at Stanford University Medical Center. RESULTS: The actuarial 5-year event-free survival (EFS) rate was 44%, the relapse rate 47%, and the regimen-related mortality (RRM) rate 8.6%. Disease status at time of transplantation, categorized as either minimal or advanced disease, was the strongest predictive factor for EFS (relative risk (RR) for advanced-disease group, 1.8; P < .0003) and relapse rate (RR for advanced-disease group, 1.9; P < .0004). Patients with minimal or advanced disease had an EFS rate of 48% and 30% and relapse rates of 43% and 72%, respectively. The EFS rate of patients less than 50 years verus > or = 50 years of age was 46% versus 34% (P = .03). Cox regression analysis showed that age was predictive for EFS (RR for patients 50 to 65 years, 1.4; P = .03). The actuarial RRM rate for these age groups was 7.4% versus 12.7% (P = .07), respectively. Multivariate analysis demonstrated that age (odds ratio [OR] for patients 50 to 65 years, 1.9; P < .05) and period of transplantation (OR for most recent years [1991 to 1995], 0.6; P = .06) were the most predictive factors for RRM. CONCLUSION: Although age greater than 50 years is associated with an inferior outcome following autologous hematopoietic-cell transplantation, it does not appear to be warranted to limit this potentially curative procedure based solely on age. The upper age limit of high-dose therapy with autologous progenitor-cell and/ or bone marrow support remains to be defined.

Duke Scholars

Published In

J Clin Oncol

DOI

ISSN

0732-183X

Publication Date

January 1997

Volume

15

Issue

1

Start / End Page

18 / 25

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Recurrence
  • Oncology & Carcinogenesis
  • Multivariate Analysis
  • Multiple Myeloma
  • Middle Aged
  • Lymphoma, Non-Hodgkin
  • Leukemia, Myeloid, Acute
  • Infant
 

Citation

APA
Chicago
ICMJE
MLA
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Kusnierz-Glaz, C. R., Schlegel, P. G., Wong, R. M., Schriber, J. R., Chao, N. J., Amylon, M. D., … Long, G. D. (1997). Influence of age on the outcome of 500 autologous bone marrow transplant procedures for hematologic malignancies. J Clin Oncol, 15(1), 18–25. https://doi.org/10.1200/JCO.1997.15.1.18
Kusnierz-Glaz, C. R., P. G. Schlegel, R. M. Wong, J. R. Schriber, N. J. Chao, M. D. Amylon, W. W. Hu, et al. “Influence of age on the outcome of 500 autologous bone marrow transplant procedures for hematologic malignancies.J Clin Oncol 15, no. 1 (January 1997): 18–25. https://doi.org/10.1200/JCO.1997.15.1.18.
Kusnierz-Glaz CR, Schlegel PG, Wong RM, Schriber JR, Chao NJ, Amylon MD, et al. Influence of age on the outcome of 500 autologous bone marrow transplant procedures for hematologic malignancies. J Clin Oncol. 1997 Jan;15(1):18–25.
Kusnierz-Glaz, C. R., et al. “Influence of age on the outcome of 500 autologous bone marrow transplant procedures for hematologic malignancies.J Clin Oncol, vol. 15, no. 1, Jan. 1997, pp. 18–25. Pubmed, doi:10.1200/JCO.1997.15.1.18.
Kusnierz-Glaz CR, Schlegel PG, Wong RM, Schriber JR, Chao NJ, Amylon MD, Hu WW, Negrin RS, Lee Y, Blume KG, Long GD. Influence of age on the outcome of 500 autologous bone marrow transplant procedures for hematologic malignancies. J Clin Oncol. 1997 Jan;15(1):18–25.

Published In

J Clin Oncol

DOI

ISSN

0732-183X

Publication Date

January 1997

Volume

15

Issue

1

Start / End Page

18 / 25

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Recurrence
  • Oncology & Carcinogenesis
  • Multivariate Analysis
  • Multiple Myeloma
  • Middle Aged
  • Lymphoma, Non-Hodgkin
  • Leukemia, Myeloid, Acute
  • Infant