Molecular characterization of MHC class II antigens (beta 1 domain) in the BB diabetes-prone and -resistant rat.


Journal Article

The BB or BB/Worcester (BB/W) rat is widely recognized as a model for human insulin-dependent diabetes mellitus (IDDM). Of at least three genes implicated in genetic susceptibility to IDDM in this strain, one is clearly linked to the major histocompatibility complex (MHC). In an attempt to define the diabetogenic gene(s) linked to the MHC of the BB rat, cDNA clones encoding the class II MHC gene products of the BB diabetes-prone and diabetes-resistant sublines have been isolated and sequenced. For comparison, the beta 1 domain of class II genes of the Lewis rat (RT1L) were sequenced. Analysis of the sequence data reveals that the first domain of RT1.D beta and RT1.B beta chain of the BB rat are different from other rat or mouse class II sequences. However, these sequences were identical in both the BB diabetes-prone and BB diabetes-resistant sublines. The significance of these findings is discussed in relation to MHC class II sequence data in IDDM patients and in the nonobese diabetic (NOD) mouse strain.

Full Text

Duke Authors

Cited Authors

  • Chao, NJ; Timmerman, L; McDevitt, HO; Jacob, CO

Published Date

  • 1989

Published In

Volume / Issue

  • 29 / 4

Start / End Page

  • 231 - 234

PubMed ID

  • 2784784

Pubmed Central ID

  • 2784784

International Standard Serial Number (ISSN)

  • 0093-7711

Digital Object Identifier (DOI)

  • 10.1007/BF00717906


  • eng

Conference Location

  • United States