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Fractionated total-body irradiation and high-dose etoposide as a preparatory regimen for bone marrow transplantation for 94 patients with chronic myelogenous leukemia in chronic phase.

Publication ,  Journal Article
Snyder, DS; Negrin, RS; O'Donnell, MR; Chao, NJ; Amylon, MD; Long, GD; Nademanee, AP; Stein, AS; Parker, PM; Smith, EP
Published in: Blood
September 1, 1994

Ninety-four consecutive patients with chronic myelogenous leukemia in first clinical chronic phase, median age of 34.0 years (range, 6.8 to 52.4 years), with a histocompatible sibling donor, were treated with fractionated total body irradiation (1,320 cGy) and high-dose etoposide (60 mg/kg) followed by allogeneic bone marrow transplantation (BMT). The median time from diagnosis to BMT was 7.0 months (range, 2.3 to 72.0 months). Sixty patients were treated before BMT with hydroxyurea alone, four patients with busulfan alone, one patient with interferon alone, and the other 29 patients were treated with various combinations of these drugs. Cumulative probabilities of overall survival, event-free survival, and relapse at 5 years were 73%, 64%, and 14%, respectively. The median follow-up time for surviving patients was 38 months, ranging from 12 to 88 months. By stepwise Cox regression analysis, significant prognostic variables were age at transplant, acute graft-versus-host disease > or = grade II, cytomegalovirus-associated interstitial pneumonitis, and years from diagnosis to BMT.

Duke Scholars

Published In

Blood

ISSN

0006-4971

Publication Date

September 1, 1994

Volume

84

Issue

5

Start / End Page

1672 / 1679

Location

United States

Related Subject Headings

  • Whole-Body Irradiation
  • Survival Rate
  • Recurrence
  • Middle Aged
  • Methylprednisolone
  • Methotrexate
  • Male
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Immunosuppression Therapy
  • Immunology
 

Citation

APA
Chicago
ICMJE
MLA
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Snyder, D. S., Negrin, R. S., O’Donnell, M. R., Chao, N. J., Amylon, M. D., Long, G. D., … Smith, E. P. (1994). Fractionated total-body irradiation and high-dose etoposide as a preparatory regimen for bone marrow transplantation for 94 patients with chronic myelogenous leukemia in chronic phase. Blood, 84(5), 1672–1679.
Snyder, D. S., R. S. Negrin, M. R. O’Donnell, N. J. Chao, M. D. Amylon, G. D. Long, A. P. Nademanee, A. S. Stein, P. M. Parker, and E. P. Smith. “Fractionated total-body irradiation and high-dose etoposide as a preparatory regimen for bone marrow transplantation for 94 patients with chronic myelogenous leukemia in chronic phase.Blood 84, no. 5 (September 1, 1994): 1672–79.
Snyder DS, Negrin RS, O’Donnell MR, Chao NJ, Amylon MD, Long GD, Nademanee AP, Stein AS, Parker PM, Smith EP. Fractionated total-body irradiation and high-dose etoposide as a preparatory regimen for bone marrow transplantation for 94 patients with chronic myelogenous leukemia in chronic phase. Blood. 1994 Sep 1;84(5):1672–1679.

Published In

Blood

ISSN

0006-4971

Publication Date

September 1, 1994

Volume

84

Issue

5

Start / End Page

1672 / 1679

Location

United States

Related Subject Headings

  • Whole-Body Irradiation
  • Survival Rate
  • Recurrence
  • Middle Aged
  • Methylprednisolone
  • Methotrexate
  • Male
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Immunosuppression Therapy
  • Immunology