Discriminative-stimulus and participant-rated effects of methylphenidate, bupropion, and triazolam in d-amphetamine-trained humans.

Journal Article (Clinical Trial;Journal Article)

The discriminative-stimulus and participate-rated effects of a range of doses of d-amphetamine (2.5-20 mg), methylphenidate (5-40 mg), bupropion (50-400 mg), and triazolam (0.0625-0.5 mg) were tested in 5 humans trained to discriminate between oral d-amphetamine (20 mg) and placebo. d-Amphetamine and methylphenidate generally dose dependently increased drug-appropriate responding. Bupropion and triazolam on average occasioned less than or equal to 40% drug-appropriate responding. d-Amphetamine, methylphenidate, and bupropion produced stimulant-like participant-rated effects, while triazolam produced sedative-like effects. These results further demonstrate that the acute behavioral effects of d-amphetamine and methylphenidate overlap extensively in humans, which is concordant with preclinical studies. Bupropion produced some d-amphetamine-like, participant-rated drug effects but did not occasion significant levels of d-amphetamine-appropriate responding. These findings are concordant with previous findings of a dissociation between the discriminative-stimulus and participant-rated effects of drugs.

Full Text

Duke Authors

Cited Authors

  • Rush, CR; Kollins, SH; Pazzaglia, PJ

Published Date

  • February 1998

Published In

Volume / Issue

  • 6 / 1

Start / End Page

  • 32 - 44

PubMed ID

  • 9526144

International Standard Serial Number (ISSN)

  • 1064-1297

Digital Object Identifier (DOI)

  • 10.1037//1064-1297.6.1.32


  • eng

Conference Location

  • United States