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Discriminative-stimulus and participant-rated effects of methylphenidate, bupropion, and triazolam in d-amphetamine-trained humans.

Publication ,  Journal Article
Rush, CR; Kollins, SH; Pazzaglia, PJ
Published in: Exp Clin Psychopharmacol
February 1998

The discriminative-stimulus and participate-rated effects of a range of doses of d-amphetamine (2.5-20 mg), methylphenidate (5-40 mg), bupropion (50-400 mg), and triazolam (0.0625-0.5 mg) were tested in 5 humans trained to discriminate between oral d-amphetamine (20 mg) and placebo. d-Amphetamine and methylphenidate generally dose dependently increased drug-appropriate responding. Bupropion and triazolam on average occasioned less than or equal to 40% drug-appropriate responding. d-Amphetamine, methylphenidate, and bupropion produced stimulant-like participant-rated effects, while triazolam produced sedative-like effects. These results further demonstrate that the acute behavioral effects of d-amphetamine and methylphenidate overlap extensively in humans, which is concordant with preclinical studies. Bupropion produced some d-amphetamine-like, participant-rated drug effects but did not occasion significant levels of d-amphetamine-appropriate responding. These findings are concordant with previous findings of a dissociation between the discriminative-stimulus and participant-rated effects of drugs.

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Published In

Exp Clin Psychopharmacol

DOI

ISSN

1064-1297

Publication Date

February 1998

Volume

6

Issue

1

Start / End Page

32 / 44

Location

United States

Related Subject Headings

  • Triazolam
  • Substance Abuse
  • Psychomotor Performance
  • Middle Aged
  • Methylphenidate
  • Male
  • Humans
  • Heart Rate
  • GABA Modulators
  • Female
 

Citation

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Rush, C. R., Kollins, S. H., & Pazzaglia, P. J. (1998). Discriminative-stimulus and participant-rated effects of methylphenidate, bupropion, and triazolam in d-amphetamine-trained humans. Exp Clin Psychopharmacol, 6(1), 32–44. https://doi.org/10.1037//1064-1297.6.1.32
Rush, C. R., S. H. Kollins, and P. J. Pazzaglia. “Discriminative-stimulus and participant-rated effects of methylphenidate, bupropion, and triazolam in d-amphetamine-trained humans.Exp Clin Psychopharmacol 6, no. 1 (February 1998): 32–44. https://doi.org/10.1037//1064-1297.6.1.32.
Rush, C. R., et al. “Discriminative-stimulus and participant-rated effects of methylphenidate, bupropion, and triazolam in d-amphetamine-trained humans.Exp Clin Psychopharmacol, vol. 6, no. 1, Feb. 1998, pp. 32–44. Pubmed, doi:10.1037//1064-1297.6.1.32.

Published In

Exp Clin Psychopharmacol

DOI

ISSN

1064-1297

Publication Date

February 1998

Volume

6

Issue

1

Start / End Page

32 / 44

Location

United States

Related Subject Headings

  • Triazolam
  • Substance Abuse
  • Psychomotor Performance
  • Middle Aged
  • Methylphenidate
  • Male
  • Humans
  • Heart Rate
  • GABA Modulators
  • Female