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Effects of training dose on the relationship between discriminative-stimulus and self-reported drug effects of d-amphetamine in humans.

Publication ,  Journal Article
Kollins, SH; Rush, CR
Published in: Pharmacol Biochem Behav
October 1999

The aim of the present experiment was to examine the relationship between the discriminative-stimulus and self-reported effects of drugs in humans. To accomplish this aim, nine healthy adult volunteers (four females, five males) were trained to discriminate between placebo and 10 mg d-amphetamine (low-dose group) or 20 mg d-amphetamine (high-dose group). After acquiring the placebo-amphetamine discrimination, a range of doses of d-amphetamine (1.25-20 mg) was tested to determine if they shared discriminative stimulus effects with the training dose. Participants in the low-dose group exhibited a significant leftward shift in the dose-response function for discrimination performance, which is concordant with previous preclinical and human drug discrimination studies that assessed the effects of training dose. Consistent with the drug discrimination findings, participants in the low-dose group exhibited a significant leftward shift in the dose-response function for several self-reported drug effects (e.g., Like the Drug and Stimulated). However, several other self-reported drug effect items were not significantly influenced by training condition (e.g., Anxious/Nervous and Bad Effects). These results suggest that the discriminative-stimulus and self-reported drug effects of d-amphetamine overlap, but are not isomorphic. Furthermore, these results illustrate that behavioral history significantly influences subsequent drug effects in humans.

Duke Scholars

Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

October 1999

Volume

64

Issue

2

Start / End Page

319 / 326

Location

United States

Related Subject Headings

  • Surveys and Questionnaires
  • Social Behavior
  • Nicotinic Agonists
  • Nicotine
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Hydromorphone
  • Humans
  • Female
 

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Kollins, S. H., & Rush, C. R. (1999). Effects of training dose on the relationship between discriminative-stimulus and self-reported drug effects of d-amphetamine in humans. Pharmacol Biochem Behav, 64(2), 319–326. https://doi.org/10.1016/s0091-3057(99)00084-2
Kollins, S. H., and C. R. Rush. “Effects of training dose on the relationship between discriminative-stimulus and self-reported drug effects of d-amphetamine in humans.Pharmacol Biochem Behav 64, no. 2 (October 1999): 319–26. https://doi.org/10.1016/s0091-3057(99)00084-2.
Kollins, S. H., and C. R. Rush. “Effects of training dose on the relationship between discriminative-stimulus and self-reported drug effects of d-amphetamine in humans.Pharmacol Biochem Behav, vol. 64, no. 2, Oct. 1999, pp. 319–26. Pubmed, doi:10.1016/s0091-3057(99)00084-2.
Journal cover image

Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

October 1999

Volume

64

Issue

2

Start / End Page

319 / 326

Location

United States

Related Subject Headings

  • Surveys and Questionnaires
  • Social Behavior
  • Nicotinic Agonists
  • Nicotine
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Hydromorphone
  • Humans
  • Female