Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1.

Journal Article

By virtue of sequence similarity, the genes encoding CD2, CD48, CD58, and Ly-9 have been assigned to a distinct subset within the immunoglobulin superfamily. Previous gene mapping studies in human and mouse have suggested that CD2, CD48, and CD58 arose by gene duplication. Here we show the gene encoding Ly-9 to be located adjacent to CD48 and the Na,K-ATPase alpha 2 subunit gene on human and mouse chromosome 1. The proximity in human and mouse genomes of the genes encoding CD2, CD58, and the Na,K-ATPase alpha 1 subunit, and of the Ly-9, CD48, and the Na,K-ATPase alpha 2 subunit genes may be explained by the occurrence of two, successive duplication events during vertebrate evolution, and suggest that Ly-9 may also participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction.

Full Text

Duke Authors

Cited Authors

  • Kingsmore, SF; Souryal, CA; Watson, ML; Patel, DD; Seldin, MF

Published Date

  • 1995

Published In

Volume / Issue

  • 42 / 1

Start / End Page

  • 59 - 62

PubMed ID

  • 7797269

International Standard Serial Number (ISSN)

  • 0093-7711

Language

  • eng

Conference Location

  • United States