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CXCR3 and CCR5 ligands in rheumatoid arthritis synovium.

Publication ,  Journal Article
Patel, DD; Zachariah, JP; Whichard, LP
Published in: Clin Immunol
January 2001

The pathogenesis of rheumatoid arthritis (RA) may be mediated by Th1-type T cells. Since chemokine receptors CXCR3 and CCR5 are preferentially expressed on Th1 cells, we tested the expression and regulation of several chemokines, including those that signal through CXCR3 (interferon-gamma-inducible protein of 10 kDa, IP-10, CXCL10; and monokine induced by interferon-gamma, Mig, CXCL9) and CCR5 (macrophage inflammatory protein (Mip)-1 alpha, CCL3; and Mip-1 beta, CCL4) in RA synovial fluids, synovial tissues, and blood. Synovial fluid (SF) protein levels of IP-10 (32.1 +/- 10.5 ng/ml), Mig (15.0 +/- 6.4 ng/ml), Mip-1 beta (0.7 +/- 0.3 ng/ml), and Mip-1 alpha (0.8 +/- 0.1 ng/ml) were 100-, 50-, 25-, and 2-fold elevated in RASF compared to control SF (P < 0.001, P < 0.001, P < 0. 001, and P < 0.02, respectively). Tissue levels of IP-10, Mig, and Mip-1 beta were significantly higher in RA than in OA (P < 0.01). Serum levels of IP-10 (3.1 +/- 1.2 ng/ml) were higher in patients with seropositive RA compared to controls (1.2 +/- 0.2 ng/ml) (P < 0.02). There was a gradient of IP-10, Mig, Mip-1 alpha, and Mip-1 beta from the blood into the synovial fluid in RA. Infiltrating T cells around high endothelial venules in RA synovium and 90 +/- 3% of SF CD3(+)CD4(+) T cells expressed CXCR3, and 85 +/- 2% of SF CD3(+)CD4(+) T cells expressed CCR5. Chemokines, including IP-10, Mig, Mip-1 alpha, and Mip-1 beta, may participate in the selective recruitment of CCR5(+)CXCR3(+) T cells to the inflamed synovium.

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Published In

Clin Immunol

DOI

ISSN

1521-6616

Publication Date

January 2001

Volume

98

Issue

1

Start / End Page

39 / 45

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Synovial Membrane
  • Receptors, Chemokine
  • Receptors, CXCR3
  • Receptors, CCR5
  • Immunology
  • Humans
  • Chemokines
  • Arthritis, Rheumatoid
  • 3204 Immunology
 

Citation

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Patel, D. D., Zachariah, J. P., & Whichard, L. P. (2001). CXCR3 and CCR5 ligands in rheumatoid arthritis synovium. Clin Immunol, 98(1), 39–45. https://doi.org/10.1006/clim.2000.4957
Patel, D. D., J. P. Zachariah, and L. P. Whichard. “CXCR3 and CCR5 ligands in rheumatoid arthritis synovium.Clin Immunol 98, no. 1 (January 2001): 39–45. https://doi.org/10.1006/clim.2000.4957.
Patel DD, Zachariah JP, Whichard LP. CXCR3 and CCR5 ligands in rheumatoid arthritis synovium. Clin Immunol. 2001 Jan;98(1):39–45.
Patel, D. D., et al. “CXCR3 and CCR5 ligands in rheumatoid arthritis synovium.Clin Immunol, vol. 98, no. 1, Jan. 2001, pp. 39–45. Pubmed, doi:10.1006/clim.2000.4957.
Patel DD, Zachariah JP, Whichard LP. CXCR3 and CCR5 ligands in rheumatoid arthritis synovium. Clin Immunol. 2001 Jan;98(1):39–45.
Journal cover image

Published In

Clin Immunol

DOI

ISSN

1521-6616

Publication Date

January 2001

Volume

98

Issue

1

Start / End Page

39 / 45

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Synovial Membrane
  • Receptors, Chemokine
  • Receptors, CXCR3
  • Receptors, CCR5
  • Immunology
  • Humans
  • Chemokines
  • Arthritis, Rheumatoid
  • 3204 Immunology